دورية أكاديمية
CYTOGENETIC DAMAGES IN LUNG CANCER PATIENTS TREATED BY EXTERNAL RADIATION THERAPY.
| العنوان: | CYTOGENETIC DAMAGES IN LUNG CANCER PATIENTS TREATED BY EXTERNAL RADIATION THERAPY. |
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| عنوان ترانسليتريتد: | TsYTOGENETYChNI POShKODZhENNIa U KhVORYKh NA RAK LEGENI PRY DYSTANTsIY̆NIY̆ PROMENEVIY̆ TERAPIÏ. |
| المؤلفون: | Maznyk N; State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science ofUkraine», 82 Pushkinska St., Kharkiv, 61024, Ukraine., Sypko T; State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science ofUkraine», 82 Pushkinska St., Kharkiv, 61024, Ukraine., Starenkiy V; State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science ofUkraine», 82 Pushkinska St., Kharkiv, 61024, Ukraine., Bohatyrenko N; State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science ofUkraine», 82 Pushkinska St., Kharkiv, 61024, Ukraine., Bilozor N; State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science ofUkraine», 82 Pushkinska St., Kharkiv, 61024, Ukraine. |
| المصدر: | Problemy radiatsiinoi medytsyny ta radiobiolohii [Probl Radiac Med Radiobiol] 2019 Dec; Vol. 24, pp. 411-425. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Ukrainian |
| بيانات الدورية: | Publisher: Naukovyĭ t︠s︡entr radiat︠s︡iĭnoï medyt︠s︡yny AMN Ukraïny Country of Publication: Ukraine NLM ID: 101560511 Publication Model: Print Cited Medium: Internet ISSN: 2313-4607 (Electronic) Linking ISSN: 23048336 NLM ISO Abbreviation: Probl Radiac Med Radiobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyïv : Naukovyĭ t︠s︡entr radiat︠s︡iĭnoï medyt︠s︡yny AMN Ukraïny |
| مواضيع طبية MeSH: | Chromosome Aberrations/*radiation effects , Gamma Rays/*adverse effects , Lung Neoplasms/*radiotherapy , Lymphocytes/*radiation effects, Aged ; Case-Control Studies ; Cytogenetic Analysis ; DNA Damage ; Dose-Response Relationship, Radiation ; Female ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lymphocytes/metabolism ; Male ; Middle Aged ; Radiation Dosage |
| مستخلص: | Objective: to estimate the chromosome type aberrations outcome in lung cancer patients during radiation therapy course depending on radiation energy. Materials and Methods: Chromosome aberrations were studied in 16 lung cancer patients examined before treat- ment in the middle and at the end of external gamma-radiotherapy 60Со on ROCUS-AM and megavolt therapy on lin- ear accelerator Clinac 600C. Results: The radiation-induced chromosome aberrations outcome in lung cancer patients during radiotherapy with different irradiation sources was studied. The over-spontaneous excess of chromosome type aberrations in cancer patients before treatment was shown. The similar and different features of cytogenetic damage accumulation dur- ing radiation therapy regarding to radiation type was displayed. The cytogenetic damage frequency raised during the course of therapeutic exposure in both studied groups. At the same time, the growth rate depended on the irra- diation regimen and was higher for patients undergoing 60Co gamma-therapy. The different range of cells with unsta- ble chromosome aberrations from the beginning to the end of the radiation therapy course was displayed. In the middle of the course the number of aberrations per aberrant cell was similar - 1-5 damages for gamma therapy, 1-4 damages for megavoltage therapy. At the end of treatment the maximum of 10 aberrations per aberrant cell for ROCUS-AM and in 5 aberrations per aberrant cell for linear accelerator was observed. During radiotherapy the distri- butions of radiation-induced chromosome aberrations was found to be over-dispersed according to Poisson statis- tic in both patients' groups. Conclusions: The study of chromosome type aberration revealed the particularities of cytogenetic damages out- come during radiotherapy course depending on the irradiation source used. The more pronounced genotoxic effect in blood lymphocytes of lung cancer patients due to gamma-irradiation with ROCUS-AM was demonstra- ted despite the higher radiation energy used on a linear accelerator. Therefore, in radiation treatment effects estimation it is necessary to take into account not only the radiation quality and energy, but also the source, regimen and pre-radiotherapy procedures. The data obtained can contribute to the assessment of the conse- quences of local fractionated irradiation and to the development of a reference biodosimetry system in radia- tion therapy. (N. Maznyk, T. Sypko, V. Starenkiy, N. Bohatyrenko, N. Bilozor.) |
| فهرسة مساهمة: | Keywords: biological dosimetry; chromosome type aberrations; external radiation therapy; lung cancer patients Local Abstract: [Publisher, Ukrainian] Meta: otsinka rivnia aberatsiy̆ khromosomnogo typu u khvorykh na rak legeni pid chas promenevogo likuvannia zalezhno vid energiy̆ oprominennia.Materialy i metody. Khromosomni aberatsiï bulo doslidzheno u 16 khvorykh na rak legeni do pochatku promenevogo likuvannia, v seredyni kursu i v kintsi dystantsiy̆noï gamma-terapiï 60So na aparati ROKUS-AM ta megavol'tnoï te- rapiï na liniy̆nomu pryskoriuvachi Clinac 600C.Rezul'taty. Vyvcheno kharakter dynamiky radiatsiy̆no-indukovanykh aberatsiy̆ khromosom u khvorykh na rak legeni vprodovzh dystantsiy̆noï promenevoï terapiï vid riznykh dzherel oprominennia. Pokazano perevyshchennia dopromene- vogo rivnia aberatsiy̆ khromosomnogo typu u onkologichnykh khvorykh nad spontannym. Bulo vyiavleno podibni ta vidminni osoblyvosti nakopychennia tsytogenetychnykh poshkodzhen' zalezhno vid vykorystanykh dzherel oprominen- nia. Chastota tsytogenetychnykh ushkodzhen' u doslidzhuvanykh grupakh zrostala protiagom vs'ogo kursu terapevtychno- go oprominennia, prychomu shvydkist' zrostannia zalezhala vid skhemy likuvannia i bula vyshchoiu u patsiientiv, do iakykh bula zastosovana gamma-terapiï 60So. Rozshyrennia spektru klityn z nestabil'nymy khromosomnymy aberatsiiamy vid pochatku do zakinchennia kursu promenevogo likuvannia takozh vidbuvalos' z riznoiu intensyvnistiu. V seredyni kur- su vidmichaly podibnu kil'kist' aberatsiy̆ na aberantnu klitynu – 1–5 poshkodzhen' dlia gamma-terapiï, 1–4 poshkod- zhennia dlia megavol'tnoï terapiï. Pislia zakinchennia likuvannia na aparati ROKUS-AM maksymum stanovyv 10 abe- ratsiy̆ na aberantnu klitynu, na liniy̆nomu pryskoriuvachi – 5 aberatsiy̆. Pid chas promenevoï terapiï v obokh grupakh rozpodily chastot radiatsiy̆no-indukovanykh aberatsiy̆ khromosom buly naddyspersnymy vidnosno statystyky Puas- sona.Vysnovky. Doslidzhennia tsytogenetychnykh poshkodzhen' khromosomnogo typu vyiavylo osoblyvosti dynamiky tsykh pokaznykiv vprodovzh promenevoï terapiï zalezhno vid dzherela oprominennia. Rezul'taty doslidzhennia vkazuiut' na bil'shyy̆ genotoksychnyy̆ efekt u limfotsytakh krovi khvorykh na rak legeni za diï gamma-oprominennia na aparati ROKUS-AM, popry vyshchu energiiu oprominennia na liniy̆nomu pryskoriuvachi. Tomu pry otsintsi efektiv promenevoï terapiï neobkhidno vrakhovuvaty ne til'ky iakist' ta energiiu vyprominiuvannia, ale y̆ dzherelo, rezhym ta peredpro- menevi protsedury. Otrymani dani ie neobkhidnymy dlia rozshyrennia uiavlen' pro naslidky lokal'nogo fraktsiono- vanogo oprominennia ta vodnochas spryiatymut' rozroblenniu referentnoï systemy biodozymetriï u promeneviy̆ terapiï. |
| تواريخ الأحداث: | Date Created: 20191217 Date Completed: 20200727 Latest Revision: 20200727 |
| رمز التحديث: | 20231215 |
| DOI: | 10.33145/2304-8336-2019-24-411-425 |
| PMID: | 31841483 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2313-4607 |
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| DOI: | 10.33145/2304-8336-2019-24-411-425 |