دورية أكاديمية
Antibody-directed metal-organic framework nanoparticles for targeted drug delivery.
| العنوان: | Antibody-directed metal-organic framework nanoparticles for targeted drug delivery. |
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| المؤلفون: | Cherkasov VR; Moscow Institute of Physics and Technology (National Research University), 9 Institutskii per., 141700, Dolgoprudny, Moscow Region, Russia; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St, 119991, Moscow, Russia., Mochalova EN; Moscow Institute of Physics and Technology (National Research University), 9 Institutskii per., 141700, Dolgoprudny, Moscow Region, Russia; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St, 119991, Moscow, Russia., Babenyshev AV; Moscow Institute of Physics and Technology (National Research University), 9 Institutskii per., 141700, Dolgoprudny, Moscow Region, Russia; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St, 119991, Moscow, Russia., Rozenberg JM; Moscow Institute of Physics and Technology (National Research University), 9 Institutskii per., 141700, Dolgoprudny, Moscow Region, Russia., Sokolov IL; Moscow Institute of Physics and Technology (National Research University), 9 Institutskii per., 141700, Dolgoprudny, Moscow Region, Russia., Nikitin MP; Moscow Institute of Physics and Technology (National Research University), 9 Institutskii per., 141700, Dolgoprudny, Moscow Region, Russia; Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia. Electronic address: max.nikitin@phystech.edu. |
| المصدر: | Acta biomaterialia [Acta Biomater] 2020 Feb; Vol. 103, pp. 223-236. Date of Electronic Publication: 2019 Dec 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford, UK : Elsevier, c2004- |
| مواضيع طبية MeSH: | Drug Delivery Systems*, Antibodies/*pharmacology , Magnetite Nanoparticles/*chemistry , Metal-Organic Frameworks/*immunology, Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Magnetite Nanoparticles/ultrastructure ; Metal-Organic Frameworks/ultrastructure |
| مستخلص: | Nanosized metal-organic frameworks (nMOFs) have shown great promise as high-capacity carriers for a variety of applications. For biomedicine, numerous nMOFs have been proposed that can transport virtually any molecular drug, can finely tune their payload release profile, etc. However, perspectives of their applications for the targeted drug delivery remain relatively unclear. So far, only a few works have reported specific cell targeting by nMOFs exclusively through small ligands such as folic acid or RGD peptides. Here we show feasibility of targeted drug delivery to specific cancer cells in vitro with nMOFs functionalized with such universal tool as an antibody. We demonstrate ca. 120 nm magnetic core/MOFs shell nanoagents loaded with doxorubicin/daunorubicin and coupled with an antibody though a hydrophilic carbohydrate interface. We show that carboxymethyl-dextran coating of nMOFs allows extensive loading of the drug molecules (up to 15.7 mg/g), offers their sustained release in physiological media and preserves antibody specificity. Reliable performance of the agents is illustrated with trastuzumab-guided selective targeting and killing of HER2/neu-positive breast cancer cells in vitro. The approach expands the scope of nMOF applications and can serve as a platform for the development of potent theranostic nanoagents. STATEMENT OF SIGNIFICANCE: The unique combination of exceptional drug capacity and controlled release, biodegradability and low toxicity makes nanosized metal-organic frameworks (nMOFs) nearly ideal drug vehicles for various biomedical applications. Unfortunately, the prospective of nMOF applications for the targeted drug delivery is still unclear since only a few examples have been reported for nMOF cell targeting, exclusively for small ligands. In this work, we fill the important gap and demonstrate nanoagent that can specifically kill target cancer cells via drug delivery based on recognition of HER2/neu cell surface receptors by such universal and specific tool as antibodies. The proposed approach is universal and can be adapted for specific biomedical tasks using antibodies of any specificity and nMOFs of a various composition. (Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer cell targeting; Core-shell hybrid structures; Daunorubicin; Doxorubicin; HER2/neu; MIL-100; Magnetic nanoparticles; Targeted drug delivery; Theranostics |
| المشرفين على المادة: | 0 (Antibodies) 0 (Magnetite Nanoparticles) 0 (Metal-Organic Frameworks) |
| تواريخ الأحداث: | Date Created: 20191218 Date Completed: 20210127 Latest Revision: 20210127 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.actbio.2019.12.012 |
| PMID: | 31843718 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-7568 |
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| DOI: | 10.1016/j.actbio.2019.12.012 |