دورية أكاديمية
The relative risk of noncervical high-risk human papillomavirus-related (pre)malignancies after recurrent cervical intraepithelial neoplasia grade 3: A population-based study.
| العنوان: | The relative risk of noncervical high-risk human papillomavirus-related (pre)malignancies after recurrent cervical intraepithelial neoplasia grade 3: A population-based study. |
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| المؤلفون: | Loopik DL; Department of Obstetrics and Gynaecology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., Ebisch RM; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, The Netherlands., IntHout J; Department of Biostatistics, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands., Melchers WJ; Department of Medical Microbiology, Radboud university medical center, Nijmegen, The Netherlands., Massuger LF; Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, The Netherlands., Bekkers RL; Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, The Netherlands., Siebers AG; Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.; PALGA, The Nationwide Network and Registry of Histo- and Cytopathology, Houten, The Netherlands. |
| المصدر: | International journal of cancer [Int J Cancer] 2020 Aug 01; Vol. 147 (3), pp. 897-900. Date of Electronic Publication: 2019 Dec 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995- : New York, NY : Wiley-Liss Original Publication: 1966-1984 : Genève : International Union Against Cancer |
| مواضيع طبية MeSH: | Neoplasm Recurrence, Local/*epidemiology , Papillomavirus Infections/*epidemiology , Uterine Cervical Neoplasms/*epidemiology , Uterine Cervical Dysplasia/*epidemiology, Adult ; Aged ; Anus Neoplasms/epidemiology ; Anus Neoplasms/virology ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines/therapeutic use ; Vaginal Neoplasms/epidemiology ; Vaginal Neoplasms/virology ; Vulvar Neoplasms/epidemiology ; Vulvar Neoplasms/virology ; Young Adult |
| مستخلص: | Women with cervical intraepithelial neoplasia grade 3 (CIN3) have a long-lasting increased risk for noncervical high-risk human papillomavirus (hrHPV)-related (pre)malignancies. The aim of our study was to estimate this risk in women with recurrent CIN3 compared to women without a history of CIN3 and women with a single episode of CIN3. Women with a CIN3 diagnosis between 1990 and 2010 were obtained from the Dutch Pathology Registry (PALGA) and matched with a control group of women without CIN3. Analysis has been conducted in a subset of women with recurrent CIN3, defined as reoccurrence minimally 2 years post-treatment. Cases of noncervical hrHPV-related (pre)malignancies of the anus, vulva, vagina and oropharynx were identified until 2015 and incidence rate ratios (IRRs) were estimated. Then, 1,797 women with recurrent CIN3 were included with a median age of 34 years (range 18-76) and 31,594 person-years of follow-up. Women with recurrent CIN3 had an increased risk of developing noncervical hrHPV-related (pre)malignancies compared to women without CIN3 with an IRR of 25.96 (95%CI 6.32-106.58). The IRR was 2.48 (95% CI 1.87-3.30) compared to women with a single episode of CIN3. Studies on posttreatment follow-up and prophylactic hrHPV vaccination are warranted. (© 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.) |
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| فهرسة مساهمة: | Keywords: case-control studies; cervical intraepithelial Neoplasia; malignant neoplasms; papillomavirus infections; second primary neoplasms |
| المشرفين على المادة: | 0 (Papillomavirus Vaccines) |
| تواريخ الأحداث: | Date Created: 20191218 Date Completed: 20210311 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7318313 |
| DOI: | 10.1002/ijc.32834 |
| PMID: | 31846057 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0215 |
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| DOI: | 10.1002/ijc.32834 |