Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.

التفاصيل البيبلوغرافية
العنوان:	Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin.
المؤلفون:	Low ZJ; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Xiong J; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg and School of Pharmacy, Fudan University, Shanghai, China., Xie Y; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Ma GL; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Saw H; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Thi Tran H; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Wong SL; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Pang LM; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Fong J; The Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore., Lu P; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Hu JF; School of Pharmacy, Fudan University, Shanghai, China., Yang L; School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China., Miao Y; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg., Liang ZX; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. zxliang@ntu.edu.sg yansongm@ntu.edu.sg and The Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore.
المصدر:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 16; Vol. 56 (5), pp. 822-825. Date of Electronic Publication: 2019 Dec 18.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Cambridge : Royal Society of Chemistry
مواضيع طبية MeSH:	Antifungal Agents/pharmacology , Fatty Alcohols/pharmacology , Polyenes/*pharmacology, Antifungal Agents/isolation & purification ; Antifungal Agents/metabolism ; Candida albicans/drug effects ; Drug Discovery ; Fatty Alcohols/isolation & purification ; Fatty Alcohols/metabolism ; Genes, Bacterial ; Genomics ; Microbial Sensitivity Tests ; Multigene Family ; Polyenes/isolation & purification ; Polyenes/metabolism ; Polyketide Synthases/genetics ; Streptomyces/chemistry
مستخلص:	Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.
التعليقات:	Erratum in: Chem Commun (Camb). 2020 Jan 3;:. (PMID: 31897459)
المشرفين على المادة:	0 (Antifungal Agents) 0 (Fatty Alcohols) 0 (Polyenes) 79956-01-7 (Polyketide Synthases)
تواريخ الأحداث:	Date Created: 20191219 Date Completed: 20200218 Latest Revision: 20200218
رمز التحديث:	20240628
DOI:	10.1039/c9cc08908j
PMID:	31848534
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1364-548X
DOI:	10.1039/c9cc08908j