دورية أكاديمية
أعرض في EDS

Meaning in life in patients with advanced cancer: a multinational study.

التفاصيل البيبلوغرافية
العنوان: Meaning in life in patients with advanced cancer: a multinational study.
المؤلفون: Gravier AL; Department of Palliative Care, Rehabilitation and Integrative Medicine, Unit 414, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA., Shamieh O; Department of Palliative Care, King Hussein Cancer Center, Amman, Jordan., Paiva CE; Department of Medical Oncology, Barretos Cancer Hospital, Barretos, Brazil., Perez-Cruz PE; Departamento Medicina Interna, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Muckaden MA; Department of Palliative Care, Tata Memorial Center, Mumbai, India., Park M; Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA., Bruera E; Department of Palliative Care, Rehabilitation and Integrative Medicine, Unit 414, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA., Hui D; Department of Palliative Care, Rehabilitation and Integrative Medicine, Unit 414, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. dhui@mdanderson.org.
المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Aug; Vol. 28 (8), pp. 3927-3934. Date of Electronic Publication: 2019 Dec 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1993-
مواضيع طبية MeSH: Existentialism*, Neoplasms/*psychology, Adult ; Aged ; Aged, 80 and over ; Anxiety/etiology ; Anxiety/psychology ; Cultural Characteristics ; Fatigue/etiology ; Fatigue/psychology ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Multivariate Analysis ; Observational Studies as Topic ; Prospective Studies ; Quality of Life ; Spirituality ; Young Adult
مستخلص: Background: Few studies have examined meaning in life, a novel existential outcome, in patients with advanced cancer across countries.
Objectives: We examined differences in meaning in life across 5 countries and identified factors associated with meaning in life.
Methods: This is a pre-planned secondary analysis of a prospective longitudinal multicenter observational study of patients with advanced cancer. Meaning in life was assessed using a validated scale which examined four domains of meaning: values, purpose, goals, and reflection. The total score ranged from 8 to 32, with a higher score indicating greater meaning in life.
Results: Among 728 patients, the median meaning in life score was 25/32 (interquartile range 23, 28). There was no significant difference in the total meaning in life score among 5 countries (P = 0.11), though there were differences in domain sub-scores. In the univariate analysis, patients with higher intensity of physical symptoms by ESAS score (pain, fatigue, drowsiness, dyspnea, insomnia), depression, anxiety, spiritual pain, and financial distress had significantly lower meaning in life. However, patients with higher levels of education, who were married, and who had higher optimism had significantly higher meaning in life. In the multivariate analysis, higher total meaning in life scores were significantly associated with greater optimism (multivariate estimate = 0.33, p < 0.001), lower depression (- 0.26, < 0.001), spiritual pain (- 0.19, < 0.001), and financial distress (- 0.16, < 0.001).
Conclusion: Country of origin was not a determinant of meaning in life. However, meaning in life was significantly associated with optimism, depression, spiritual pain, and financial distress, underscoring the multidimensional nature of this construct and potential opportunities for improvement in addressing meaning in life of patients with advanced cancer.
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معلومات مُعتمدة: P30 CA016672 United States CA NCI NIH HHS; 1R01CA225701-01A1 United States CA NCI NIH HHS; 1R21NR016736-01 United States NR NINR NIH HHS; R01 CA225701 United States CA NCI NIH HHS; 1R01CA214960-01A1 United States CA NCI NIH HHS; R01 CA214960 United States CA NCI NIH HHS; R21 NR016736 United States NR NINR NIH HHS; RSG-14-148-01-CCE American Cancer Society; n/a Sister Institution Network Fund; n/a Helsinn Therapeutics
فهرسة مساهمة: Keywords: Cultural diversity; Financial support; Neoplasms; Palliative care; Psychological stress; Spirituality
تواريخ الأحداث: Date Created: 20191221 Date Completed: 20200807 Latest Revision: 20220416
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8582319
DOI: 10.1007/s00520-019-05239-5
PMID: 31858248
قاعدة البيانات: MEDLINE
الوصف
تدمد:1433-7339
DOI:10.1007/s00520-019-05239-5