دورية أكاديمية
Genetic diversity and evolution of the emerging picornavirus Senecavirus A .
| العنوان: | Genetic diversity and evolution of the emerging picornavirus Senecavirus A . |
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| المؤلفون: | Joshi LR; Embrapa Swine and Poultry, Concórdia, Santa Catarina, Brazil.; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57007, USA.; Present address: Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Mohr KA; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57007, USA., Gava D; Embrapa Swine and Poultry, Concórdia, Santa Catarina, Brazil., Kutish G; Department of Pathobiology, University of Connecticut, Storrs, CT 06269, USA., Buysse AS; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57007, USA., Vannucci FA; Department of Population Medicine, University of Minnesota, St Paul, MN 55455, USA., Piñeyro PE; Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA., Crossley BM; California Animal Health and Food Safety Laboratory System, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA., Schiltz JJ; National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, USDA, Ames, IA, USA., Jenkins-Moore M; National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, USDA, Ames, IA, USA., Koster L; National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, USDA, Ames, IA, USA., Tell R; National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, USDA, Ames, IA, USA., Schaefer R; Embrapa Swine and Poultry, Concórdia, Santa Catarina, Brazil., Marthaler D; Veterinary Diagnostic Laboratory, Kansas State University, Manhattan, KS, USA.; Department of Population Medicine, University of Minnesota, St Paul, MN 55455, USA., Diel DG; Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57007, USA.; Present address: Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.; Embrapa Swine and Poultry, Concórdia, Santa Catarina, Brazil. |
| المصدر: | The Journal of general virology [J Gen Virol] 2020 Feb; Vol. 101 (2), pp. 175-187. Date of Electronic Publication: 2019 Dec 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 0077340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-2099 (Electronic) Linking ISSN: 00221317 NLM ISO Abbreviation: J Gen Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Microbiology Society Original Publication: London, Cambridge Univ. Press for the Society for General Microbiology. |
| مواضيع طبية MeSH: | Communicable Diseases, Emerging*/veterinary , Communicable Diseases, Emerging*/virology, Picornaviridae/*genetics , Picornaviridae Infections/*veterinary , Swine Diseases/*virology, Amino Acid Substitution/genetics ; Animals ; Disease Outbreaks ; Evolution, Molecular ; Genetic Variation ; Genome, Viral ; Phylogeny ; Picornaviridae Infections/epidemiology ; Swine ; Swine Diseases/epidemiology ; United States/epidemiology ; Viral Proteins/genetics ; Viral Structural Proteins/genetics |
| مستخلص: | Senecavirus A (SVA) is an emerging picornavirus that causes vesicular disease (VD) in swine. The virus has been circulating in swine in the United Stated (USA) since at least 1988, however, since 2014 a marked increase in the number of SVA outbreaks has been observed in swine worldwide. The factors that led to the emergence of SVA remain unknown. Evolutionary changes that accumulated in the SVA genome over the years may have contributed to the recent increase in disease incidence. Here we compared full-genome sequences of historical SVA strains (identified before 2010) from the USA and global contemporary SVA strains (identified after 2011). The results from the genetic analysis revealed 6.32 % genetic divergence between historical and contemporary SVA isolates. Selection pressure analysis revealed that the SVA polyprotein is undergoing selection, with four amino acid (aa) residues located in the VP1 (aa 735), 2A (aa 941), 3C (aa 1547) and 3D (aa 1850) coding regions being under positive/diversifying selection. Several aa substitutions were observed in the structural proteins (VP1, VP2 and VP3) of contemporary SVA isolates when compared to historical SVA strains. Some of these aa substitutions led to changes in the surface electrostatic potential of the structural proteins. This work provides important insights into the molecular evolution and epidemiology of SVA. |
| فهرسة مساهمة: | Keywords: SVV; Seneca Valley virus; Senecavirus A; evolution; genetic diversity |
| المشرفين على المادة: | 0 (Viral Proteins) 0 (Viral Structural Proteins) |
| SCR Organism: | Senecavirus A |
| تواريخ الأحداث: | Date Created: 20191221 Date Completed: 20200803 Latest Revision: 20200803 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1099/jgv.0.001360 |
| PMID: | 31859611 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1465-2099 |
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| DOI: | 10.1099/jgv.0.001360 |