دورية أكاديمية
Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications.
| العنوان: | Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications. |
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| المؤلفون: | Afewerki S; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women´s Hospital, Cambridge, MA, USA; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, MIT, Cambridge, MA, USA. Electronic address: samson.afewerki20@gmail.com., Bassous N; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Harb S; Institute of Chemistry, São Paulo State University, Araraquara, - SP, Brazil., Palo-Nieto C; Department of Medicinal Chemistry, BMC, Uppsala University, Uppsala, Sweden., Ruiz-Esparza GU; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women´s Hospital, Cambridge, MA, USA; Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, MIT, Cambridge, MA, USA., Marciano FR; Department of Physics, UFPI- Federal University of Piauí, Teresina, PI, Brazil., Webster TJ; Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, USA., Furtado ASA; LIMAV - Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI- Federal University of Piauí, Teresina, PI, Brazil., Lobo AO; LIMAV - Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI- Federal University of Piauí, Teresina, PI, Brazil; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: lobo@ufpi.edu.br. |
| المصدر: | Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2020 Feb; Vol. 24, pp. 102143. Date of Electronic Publication: 2019 Dec 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101233142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9642 (Electronic) Linking ISSN: 15499634 NLM ISO Abbreviation: Nanomedicine Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, c2005- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*chemistry , Biocompatible Materials/*chemistry , Orthopedics/*methods, Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/therapeutic use ; Bone Regeneration/drug effects ; Humans ; Osteogenesis/drug effects |
| مستخلص: | A vast growing problem in orthopaedic medicine is the increase of clinical cases with antibiotic resistant pathogenic microbes, which is predicted to cause higher mortality than all cancers combined by 2050. Bone infectious diseases limit the healing ability of tissues and increase the risk of future injuries due to pathologic tissue remodelling. The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prosthesis, all of these resulting in long-term rehabilitation. This is a huge burden to the public health system resulting in increased healthcare costs. Current technologies e.g. co-delivery systems, where antibacterial and osteoinductive agents are delivered encounter challenges such as site-specific delivery, sustained and prolonged release, and biocompatibility. In this review, these aspects are highlighted to promote the invention of the next generation biomaterials to prevent and/or treat bone infections and promote tissue regeneration. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antibacterial; Biomaterials; Orthopedic; Osteoinduction; Tissue engineering |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents) 0 (Biocompatible Materials) |
| تواريخ الأحداث: | Date Created: 20191222 Date Completed: 20201123 Latest Revision: 20201123 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.nano.2019.102143 |
| PMID: | 31862427 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1549-9642 |
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| DOI: | 10.1016/j.nano.2019.102143 |