دورية أكاديمية
Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex.
العنوان: | Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex. |
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المؤلفون: | Murase S; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Winkowski D; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Liu J; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Kanold PO; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Quinlan EM; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States. |
المصدر: | ELife [Elife] 2019 Dec 23; Vol. 8. Date of Electronic Publication: 2019 Dec 23. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Amblyopia/*metabolism , Matrix Metalloproteinase 9/*metabolism , Proteostasis/*physiology , Visual Cortex/*metabolism, Amblyopia/embryology ; Amblyopia/pathology ; Animals ; Biomarkers ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Female ; Light ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/genetics ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/physiology ; Photic Stimulation ; Plant Lectins ; Proteolysis ; Receptors, N-Acetylglucosamine ; Synapses ; Vision, Binocular/physiology ; Visual Cortex/embryology ; Visual Cortex/pathology |
مستخلص: | Dark exposure (DE) followed by light reintroduction (LRx) reactivates robust synaptic plasticity in adult mouse primary visual cortex (V1), which allows subsequent recovery from amblyopia. Previously we showed that perisynaptic proteolysis by MMP9 mediates the enhancement of plasticity by LRx in binocular adult mice (Murase et al., 2017). However, it was unknown if a visual system compromised by amblyopia could engage this pathway. Here we show that LRx to adult amblyopic mice induces perisynaptic MMP2/9 activity and extracellular matrix (ECM) degradation in deprived and non-deprived V1. Indeed, LRx restricted to the amblyopic eye is sufficient to induce robust MMP2/9 activity at thalamo-cortical synapses and ECM degradation in deprived V1. Two-photon live imaging demonstrates that the history of visual experience regulates MMP2/9 activity in V1, and that DE lowers the threshold for the proteinase activation. The homeostatic reduction of the MMP2/9 activation threshold by DE enables visual input from the amblyopic pathway to trigger robust perisynaptic proteolysis. Competing Interests: SM, DW, JL, PK, EQ No competing interests declared (© 2019, Murase et al.) |
References: | Nat Neurosci. 2010 Sep;13(9):1090-7. (PMID: 20729843) J Biol Chem. 2000 Oct 20;275(42):33038-45. (PMID: 11032846) Nat Neurosci. 2018 Jun;21(6):843-850. (PMID: 29760525) Elife. 2017 Sep 06;6:. (PMID: 28875930) Science. 2009 Sep 4;325(5945):1258-61. (PMID: 19729657) Mol Cell Neurosci. 2008 Dec;39(4):549-68. (PMID: 18817873) Vision Res. 1983;23(12):1501-10. (PMID: 6666051) Neuron. 2014 Feb 5;81(3):664-73. (PMID: 24507197) Philos Trans R Soc Lond B Biol Sci. 1991 Jul 29;333(1266):51-79. (PMID: 1682958) Front Cell Neurosci. 2015 Sep 22;9:369. (PMID: 26441540) J Neurosci. 2013 Jan 2;33(1):234-43. (PMID: 23283337) Curr Opin Neurobiol. 2019 Feb;54:44-53. (PMID: 30212714) Proc Natl Acad Sci U S A. 2006 May 30;103(22):8517-22. (PMID: 16709670) Vision Res. 2015 Sep;114:17-30. (PMID: 25637854) Proc Natl Acad Sci U S A. 1981 Jun;78(6):3950-3. (PMID: 6943591) Nature. 1995 May 25;375(6529):325-8. (PMID: 7753197) Brain Res Dev Brain Res. 1991 Feb 22;58(2):151-8. (PMID: 2029762) Nat Neurosci. 2016 May;19(5):716-724. (PMID: 26928064) Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14139-14144. (PMID: 27856748) Cereb Cortex. 2012 Mar;22(3):725-34. (PMID: 21685398) J Neurosci. 2005 Dec 14;25(50):11684-92. (PMID: 16354927) J Neurosci. 2016 Oct 5;36(40):10285-10295. (PMID: 27707966) J Cell Sci. 2001 Mar;114(Pt 5):917-30. (PMID: 11181175) Science. 2016 Jun 10;352(6291):1319-22. (PMID: 27284193) Cereb Cortex. 2016 May;26(5):1975-85. (PMID: 25662716) J Neurosci. 2007 Oct 31;27(44):12025-32. (PMID: 17978044) J Neurosci. 2013 Apr 17;33(16):7057-65. (PMID: 23595763) Curr Opin Neurol. 2017 Feb;30(1):74-83. (PMID: 28002122) Nat Neurosci. 2007 Sep;10(9):1134-6. (PMID: 17694050) Nature. 1995 May 25;375(6529):328-31. (PMID: 7753198) PLoS One. 2014 May 22;9(5):e98274. (PMID: 24853857) Nature. 1998 Feb 26;391(6670):892-6. (PMID: 9495341) Curr Opin Neurobiol. 2017 Apr;43:87-93. (PMID: 28236778) Nat Rev Neurosci. 2008 May;9(5):387. (PMID: 18401345) J Neurosci. 2012 Oct 17;32(42):14538-47. (PMID: 23077039) Brain. 2010 Aug;133(Pt 8):2331-47. (PMID: 20566484) Science. 2002 Nov 8;298(5596):1248-51. (PMID: 12424383) Neuron. 2013 Jul 24;79(2):335-46. (PMID: 23889936) J Neurobiol. 2006 May;66(6):564-77. (PMID: 16555239) Neuroscience. 2009 Feb 6;158(3):983-94. (PMID: 18621108) Nat Rev Neurosci. 2012 Nov;13(11):798-810. (PMID: 23080416) J Neurosci. 2006 Mar 15;26(11):2951-5. (PMID: 16540572) Learn Mem. 2013 May 16;20(6):311-7. (PMID: 23685763) J Comp Neurol. 2018 Feb 1;526(2):310-323. (PMID: 29023717) J Neurophysiol. 1996 Apr;75(4):1714-29. (PMID: 8727408) Exp Gerontol. 2014 Dec;60:1-11. (PMID: 25220148) J Neurophysiol. 2004 Oct;92(4):2113-21. (PMID: 15102897) Neuron. 2004 Dec 16;44(6):1031-41. (PMID: 15603745) Neuron. 2010 Jul 15;67(1):116-28. (PMID: 20624596) Mol Cell Neurosci. 2013 Sep;56:186-200. (PMID: 23665579) Mol Psychiatry. 2019 Jan;24(1):145-160. (PMID: 30242227) J Neurosci. 2016 Oct 26;36(43):11006-11012. (PMID: 27798181) Nat Neurosci. 2012 Mar 11;15(5):703-12. (PMID: 22406547) J Neurosci. 2012 Sep 26;32(39):13529-36. (PMID: 23015442) J Cell Biol. 2008 Mar 10;180(5):1021-35. (PMID: 18332222) J Neurophysiol. 2007 Jul;98(1):334-44. (PMID: 17493927) Nat Commun. 2011;2:317. (PMID: 21587234) Neuron. 2012 Oct 18;76(2):396-409. (PMID: 23083741) Nat Neurosci. 1999 Jun;2(6):515-20. (PMID: 10448215) Nat Protoc. 2014 Nov;9(11):2515-2538. (PMID: 25275789) Cell Rep. 2018 May 29;23(9):2533-2540. (PMID: 29847785) Learn Mem. 2016 Jan 19;23(2):99-103. (PMID: 26787781) Biol Psychiatry. 2015 Sep 15;78(6):396-402. (PMID: 25758057) Sci Rep. 2017 Oct 3;7(1):12646. (PMID: 28974755) J Neurosci. 1997 Mar 15;17(6):1928-39. (PMID: 9045722) Neurosci Lett. 1993 Nov 12;162(1-2):137-40. (PMID: 7510052) Philos Trans R Soc Lond B Biol Sci. 2014 Oct 19;369(1654):20140046. (PMID: 25225104) Neuron. 2016 Oct 5;92(1):160-173. (PMID: 27641496) J Neurosci. 2016 Jun 8;36(23):6312-20. (PMID: 27277807) Curr Opin Neurobiol. 2019 Feb;54:194-199. (PMID: 30120016) Neuron. 2004 Dec 16;44(6):1021-30. (PMID: 15603744) J Neurosci. 2002 Feb 1;22(3):920-30. (PMID: 11826121) J Neurosci. 2012 Jul 4;32(27):9429-37. (PMID: 22764251) Curr Biol. 2013 Mar 4;23(5):382-6. (PMID: 23416100) |
معلومات مُعتمدة: | R01DC009607 United States DC NIDCD NIH HHS; R01EY016431 United States EY NEI NIH HHS; R01 DC009607 United States DC NIDCD NIH HHS; S10 OD025223 United States OD NIH HHS; R01 EY016431 United States EY NEI NIH HHS; R01 EY025922 United States EY NEI NIH HHS |
فهرسة مساهمة: | Keywords: MMP9; amblyopia; chronic monocular deprivation; dark exposure; light reintroduction; mouse; neuroscience; two-photon |
المشرفين على المادة: | 0 (Biomarkers) 0 (Plant Lectins) 0 (Receptors, N-Acetylglucosamine) 0 (wisteria lectin) EC 3.4.24.24 (Matrix Metalloproteinase 2) EC 3.4.24.24 (Mmp2 protein, mouse) EC 3.4.24.35 (Matrix Metalloproteinase 9) EC 3.4.24.35 (Mmp9 protein, mouse) |
تواريخ الأحداث: | Date Created: 20191224 Date Completed: 20200615 Latest Revision: 20220514 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6961978 |
DOI: | 10.7554/eLife.52503 |
PMID: | 31868167 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
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DOI: | 10.7554/eLife.52503 |