دورية أكاديمية
أعرض في EDS

Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex.

التفاصيل البيبلوغرافية
العنوان: Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex.
المؤلفون: Murase S; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Winkowski D; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Liu J; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Kanold PO; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States., Quinlan EM; Department of Biology, University of Maryland, College Park, United States.; Neuroscience Cognitive Sciences Program, University of Maryland, College Park, United States.
المصدر: ELife [Elife] 2019 Dec 23; Vol. 8. Date of Electronic Publication: 2019 Dec 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Amblyopia/*metabolism , Matrix Metalloproteinase 9/*metabolism , Proteostasis/*physiology , Visual Cortex/*metabolism, Amblyopia/embryology ; Amblyopia/pathology ; Animals ; Biomarkers ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Female ; Light ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/genetics ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/physiology ; Photic Stimulation ; Plant Lectins ; Proteolysis ; Receptors, N-Acetylglucosamine ; Synapses ; Vision, Binocular/physiology ; Visual Cortex/embryology ; Visual Cortex/pathology
مستخلص: Dark exposure (DE) followed by light reintroduction (LRx) reactivates robust synaptic plasticity in adult mouse primary visual cortex (V1), which allows subsequent recovery from amblyopia. Previously we showed that perisynaptic proteolysis by MMP9 mediates the enhancement of plasticity by LRx in binocular adult mice (Murase et al., 2017). However, it was unknown if a visual system compromised by amblyopia could engage this pathway. Here we show that LRx to adult amblyopic mice induces perisynaptic MMP2/9 activity and extracellular matrix (ECM) degradation in deprived and non-deprived V1. Indeed, LRx restricted to the amblyopic eye is sufficient to induce robust MMP2/9 activity at thalamo-cortical synapses and ECM degradation in deprived V1. Two-photon live imaging demonstrates that the history of visual experience regulates MMP2/9 activity in V1, and that DE lowers the threshold for the proteinase activation. The homeostatic reduction of the MMP2/9 activation threshold by DE enables visual input from the amblyopic pathway to trigger robust perisynaptic proteolysis.
Competing Interests: SM, DW, JL, PK, EQ No competing interests declared
(© 2019, Murase et al.)
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معلومات مُعتمدة: R01DC009607 United States DC NIDCD NIH HHS; R01EY016431 United States EY NEI NIH HHS; R01 DC009607 United States DC NIDCD NIH HHS; S10 OD025223 United States OD NIH HHS; R01 EY016431 United States EY NEI NIH HHS; R01 EY025922 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: MMP9; amblyopia; chronic monocular deprivation; dark exposure; light reintroduction; mouse; neuroscience; two-photon
المشرفين على المادة: 0 (Biomarkers)
0 (Plant Lectins)
0 (Receptors, N-Acetylglucosamine)
0 (wisteria lectin)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
EC 3.4.24.24 (Mmp2 protein, mouse)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
EC 3.4.24.35 (Mmp9 protein, mouse)
تواريخ الأحداث: Date Created: 20191224 Date Completed: 20200615 Latest Revision: 20220514
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6961978
DOI: 10.7554/eLife.52503
PMID: 31868167
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.52503