دورية أكاديمية
The impact of active vitamin D administration on the clinical outcomes of acne vulgaris.
| العنوان: | The impact of active vitamin D administration on the clinical outcomes of acne vulgaris. |
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| المؤلفون: | Ahmed Mohamed A; Department of Biochemistry & Molecular Biology, National Hepatology & Tropical Medicine Research Institute, Cairo, Egypt., Salah Ahmed EM; Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine, Helwan University, Cairo, Egypt., Abdel-Aziz RTA; Department of Dermatology, STDs and Andrology, Faculty of medicine, Minia University, Minia, Egypt., Eldeeb Abdallah HH; Department of Clinical Pathology, El Sahel Teaching Hospital, Cairo, Egypt., El-Hanafi H; Clinical and Chemical Pathology, Kasr El-Einy hospitals, Cairo University, Cairo, Egypt., Hussein G; Department of Clinical Pathology, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt., Abbassi MM; Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt., El Borolossy R; Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. |
| المصدر: | The Journal of dermatological treatment [J Dermatolog Treat] 2021 Nov; Vol. 32 (7), pp. 756-761. Date of Electronic Publication: 2020 Jan 03. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8918133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-1753 (Electronic) Linking ISSN: 09546634 NLM ISO Abbreviation: J Dermatolog Treat Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Houndmills, Basingstoke, Hampshire, UK : M. Dunitz and Macmillan Press, [c1989]- |
| مواضيع طبية MeSH: | Acne Vulgaris*/drug therapy , Vitamin D Deficiency*/complications , Vitamin D Deficiency*/drug therapy, Vitamin D/*therapeutic use, Humans ; Skin |
| مستخلص: | Acne vulgaris is one of the most common chronic inflammatory skin disorder affecting millions of people worldwide. Vitamin D deficiency has a role in various inflammatory skin diseases as acne. This study aimed to investigate the serum level of 25 hydroxy vitamin D in acne patients and to assess the efficacy and safety of active vitamin D in management of acne. This study was conducted on 100 patients with acne and 100 healthy controls, then the 100 acne patients were randomized to either the study group that received 0.25ug alfacalcidol daily or the placebo group that received oral placebo during the 3 months study period. Serum levels of 25-hydroxy-vitamin D were significantly lower in acne patients than in healthy control and were inversely correlated to the severity of acne. After alfacalcidol administration, the study group showed significant higher level of 25(OH) D levels ( p < .05) compared to placebo group. In addition, median serum level of IL6 and TNFα significantly decreased ( p < .05) in the study group in comparison to placebo group and as compared to their baseline results. Acne patients are more commonly to have vitamin D deficiency as compared to healthy people and hence, alfacalcidol might have a beneficial role in the acne management with no reported side effects. |
| التعليقات: | Erratum in: J Dermatolog Treat. 2020 Jan 21;:1. (PMID: 31959012) |
| فهرسة مساهمة: | Keywords: Acne vulgaris; active Vitamin D; inflammation; interleukin 6; tumor necrosis factor alpha |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20191224 Date Completed: 20211125 Latest Revision: 20220531 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/09546634.2019.1708852 |
| PMID: | 31868550 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1471-1753 |
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| DOI: | 10.1080/09546634.2019.1708852 |