دورية أكاديمية
Retinopathy of Prematurity and Bronchopulmonary Dysplasia are Independent Antecedents of Cortical Maturational Abnormalities in Very Preterm Infants.
العنوان: | Retinopathy of Prematurity and Bronchopulmonary Dysplasia are Independent Antecedents of Cortical Maturational Abnormalities in Very Preterm Infants. |
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المؤلفون: | Kline JE; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Illapani VSP; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., He L; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Altaye M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Divison of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Parikh NA; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Nehal.Parikh@cchmc.org. |
المصدر: | Scientific reports [Sci Rep] 2019 Dec 23; Vol. 9 (1), pp. 19679. Date of Electronic Publication: 2019 Dec 23. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Bronchopulmonary Dysplasia/*complications , Cerebral Cortex/*abnormalities , Neurodevelopmental Disorders/*etiology , Retinopathy of Prematurity/*complications, Bronchopulmonary Dysplasia/diagnostic imaging ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/growth & development ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Premature ; Magnetic Resonance Imaging ; Male ; Multivariate Analysis ; Neurodevelopmental Disorders/diagnostic imaging ; Prospective Studies ; Retinopathy of Prematurity/diagnostic imaging ; Risk Factors |
مستخلص: | Very preterm (VPT) infants are at high-risk for neurodevelopmental impairments, however there are few validated biomarkers at term-equivalent age that accurately measure abnormal brain development and predict future impairments. Our objectives were to quantify and contrast cortical features between full-term and VPT infants at term and to associate two key antecedent risk factors, bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP), with cortical maturational changes in VPT infants. We prospectively enrolled a population-based cohort of 110 VPT infants (gestational age ≤31 weeks) and 51 healthy full-term infants (gestational age 38-42 weeks). Structural brain MRI was performed at term. 94 VPT infants and 46 full-term infants with high-quality T2-weighted MRI were analyzed. As compared to full-term infants, VPT infants exhibited significant global cortical maturational abnormalities, including reduced surface area (-5.9%) and gyrification (-6.7%) and increased curvature (5.9%). In multivariable regression controlled for important covariates, BPD was significantly negatively correlated with lobar and global cortical surface area and ROP was significantly negatively correlated with lobar and global sulcal depth in VPT infants. Our cohort of VPT infants exhibited widespread cortical maturation abnormalities by term-equivalent age that were in part anteceded by two of the most potent neonatal diseases, BPD and ROP. |
التعليقات: | Erratum in: Sci Rep. 2021 Mar 23;11(1):7055. (PMID: 33758237) |
References: | Neuroimage. 2016 Jan 15;125:780-790. (PMID: 26550941) Semin Perinatol. 2016 Dec;40(8):530-541. (PMID: 27863706) Neuroimage. 2015 Apr 1;109:469-79. (PMID: 25614973) Pediatrics. 2016 Nov;138(5):. (PMID: 27940782) J Clin Med. 2017 Jan 06;6(1):. (PMID: 28067830) Am J Respir Crit Care Med. 2001 Jun;163(7):1723-9. (PMID: 11401896) Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3156-3161. (PMID: 29507201) Neurology. 2011 Oct 18;77(16):1510-7. (PMID: 21998316) JAMA. 2003 Mar 5;289(9):1124-9. (PMID: 12622582) Brain. 2005 Nov;128(Pt 11):2578-87. (PMID: 16150850) J Pediatr. 1999 Sep;135(3):351-7. (PMID: 10484802) Ann Neurol. 2015 Jan;77(1):154-62. (PMID: 25425403) Dev Med Child Neurol. 2000 Jan;42(1):53-60. (PMID: 10665976) Semin Perinatol. 2019 Oct;43(6):381-389. (PMID: 31174874) Biol Open. 2016 Apr 15;5(4):475-83. (PMID: 26988760) Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F20-9. (PMID: 20736416) Neuroimage Clin. 2015 Apr 14;8:193-201. (PMID: 26106543) Neonatology. 2015;107(3):179-84. (PMID: 25632975) J Dev Behav Pediatr. 2001 Feb;22(1):19-26. (PMID: 11265919) Lancet Glob Health. 2019 Jan;7(1):e37-e46. (PMID: 30389451) Int J Imaging Syst Technol. 2008 Jun 1;18(1):42-68. (PMID: 19936261) Pediatrics. 2006 Dec;118(6):e1621-6. (PMID: 17074842) Neonatology. 2016;110(1):47-54. (PMID: 27050735) PLoS Med. 2006 Aug;3(8):e265. (PMID: 16866579) AJNR Am J Neuroradiol. 2013 Nov-Dec;34(11):2208-14. (PMID: 23620070) Pediatrics. 2015 Jan;135(1):e32-42. (PMID: 25554820) Neuroimage. 2016 Jan 15;125:456-478. (PMID: 26499811) Semin Perinatol. 2006 Aug;30(4):227-32. (PMID: 16860163) PLoS One. 2013;8(4):e59990. (PMID: 23565180) Arch Ophthalmol. 2005 Jul;123(7):991-9. (PMID: 16009843) Pediatrics. 2003 Nov;112(5):e359. (PMID: 14595077) PLoS One. 2013 May 09;8(5):e62804. (PMID: 23671636) Neuroimage. 2018 Jun;173:88-112. (PMID: 29409960) Arch Dis Child Fetal Neonatal Ed. 2017 Nov;102(6):F532-F537. (PMID: 28536205) Early Hum Dev. 2012 Jul;88(7):509-15. (PMID: 22236557) J Pediatr. 2015 Nov;167(5):982-6.e2. (PMID: 26318030) Sci Rep. 2018 Oct 22;8(1):15553. (PMID: 30349084) Pediatrics. 2003 May;111(5 Pt 1):939-48. (PMID: 12728069) Am J Epidemiol. 1989 Jan;129(1):125-37. (PMID: 2910056) Brain. 2008 Aug;131(Pt 8):2028-41. (PMID: 18587151) J Neuropsychol. 2016 Sep;10(2):276-94. (PMID: 25809467) Semin Fetal Neonatal Med. 2007 Oct;12(5):363-73. (PMID: 17625996) Pediatr Res. 2011 May;69(5 Pt 2):11R-8R. (PMID: 21289534) Am J Dis Child. 1985 Oct;139(10):1031-8. (PMID: 4036890) Dev Med Child Neurol. 1993 Jun;35(6):553-8. (PMID: 8504899) Syst Rev. 2015 May 17;4:71. (PMID: 25982565) Pediatrics. 1997 Dec;100(6):987-93. (PMID: 9374570) |
معلومات مُعتمدة: | R01 NS094200 United States NS NINDS NIH HHS; R01 NS096037 United States NS NINDS NIH HHS |
تواريخ الأحداث: | Date Created: 20191225 Date Completed: 20201109 Latest Revision: 20231027 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC6928014 |
DOI: | 10.1038/s41598-019-56298-x |
PMID: | 31873183 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-019-56298-x |