دورية أكاديمية
أعرض في EDS

Retinopathy of Prematurity and Bronchopulmonary Dysplasia are Independent Antecedents of Cortical Maturational Abnormalities in Very Preterm Infants.

التفاصيل البيبلوغرافية
العنوان: Retinopathy of Prematurity and Bronchopulmonary Dysplasia are Independent Antecedents of Cortical Maturational Abnormalities in Very Preterm Infants.
المؤلفون: Kline JE; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Illapani VSP; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., He L; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Altaye M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Divison of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Parikh NA; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Nehal.Parikh@cchmc.org.
المصدر: Scientific reports [Sci Rep] 2019 Dec 23; Vol. 9 (1), pp. 19679. Date of Electronic Publication: 2019 Dec 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Bronchopulmonary Dysplasia/*complications , Cerebral Cortex/*abnormalities , Neurodevelopmental Disorders/*etiology , Retinopathy of Prematurity/*complications, Bronchopulmonary Dysplasia/diagnostic imaging ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/growth & development ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Premature ; Magnetic Resonance Imaging ; Male ; Multivariate Analysis ; Neurodevelopmental Disorders/diagnostic imaging ; Prospective Studies ; Retinopathy of Prematurity/diagnostic imaging ; Risk Factors
مستخلص: Very preterm (VPT) infants are at high-risk for neurodevelopmental impairments, however there are few validated biomarkers at term-equivalent age that accurately measure abnormal brain development and predict future impairments. Our objectives were to quantify and contrast cortical features between full-term and VPT infants at term and to associate two key antecedent risk factors, bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP), with cortical maturational changes in VPT infants. We prospectively enrolled a population-based cohort of 110 VPT infants (gestational age ≤31 weeks) and 51 healthy full-term infants (gestational age 38-42 weeks). Structural brain MRI was performed at term. 94 VPT infants and 46 full-term infants with high-quality T2-weighted MRI were analyzed. As compared to full-term infants, VPT infants exhibited significant global cortical maturational abnormalities, including reduced surface area (-5.9%) and gyrification (-6.7%) and increased curvature (5.9%). In multivariable regression controlled for important covariates, BPD was significantly negatively correlated with lobar and global cortical surface area and ROP was significantly negatively correlated with lobar and global sulcal depth in VPT infants. Our cohort of VPT infants exhibited widespread cortical maturation abnormalities by term-equivalent age that were in part anteceded by two of the most potent neonatal diseases, BPD and ROP.
التعليقات: Erratum in: Sci Rep. 2021 Mar 23;11(1):7055. (PMID: 33758237)
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معلومات مُعتمدة: R01 NS094200 United States NS NINDS NIH HHS; R01 NS096037 United States NS NINDS NIH HHS
تواريخ الأحداث: Date Created: 20191225 Date Completed: 20201109 Latest Revision: 20231027
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6928014
DOI: 10.1038/s41598-019-56298-x
PMID: 31873183
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-56298-x