دورية أكاديمية
Impact of Surgical Margins in Breast Cancer After Preoperative Systemic Chemotherapy on Local Recurrence and Survival.
العنوان: | Impact of Surgical Margins in Breast Cancer After Preoperative Systemic Chemotherapy on Local Recurrence and Survival. |
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المؤلفون: | Wimmer K; Department of Surgery, Medical University of Vienna, Vienna, Austria.; Breast Health Centre, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria., Bolliger M; Department of Surgery, Medical University of Vienna, Vienna, Austria.; Breast Health Centre, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria., Bago-Horvath Z; Breast Health Centre, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.; Department of Pathology, Medical University of Vienna, Vienna, Austria., Steger G; Breast Health Centre, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.; Department of Oncology Medical, University of Vienna, Vienna, Austria., Kauer-Dorner D; Breast Health Centre, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.; Department of Radio-oncology, Medical University of Vienna, Vienna, Austria., Helfgott R; Department of Surgery, Ordensklinikum Linz/Hospital of the Sisters of Charity, Linz, Austria., Gruber C; Department of Pathology, Ordensklinikum Linz/Hospital of the Sisters of Charity, Linz, Austria., Moinfar F; Department of Pathology, Ordensklinikum Linz/Hospital of the Sisters of Charity, Linz, Austria., Mittlböck M; Centre for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria., Fitzal F; Department of Surgery, Medical University of Vienna, Vienna, Austria. florian.fitzal@meduniwien.ac.at.; Breast Health Centre, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria. florian.fitzal@meduniwien.ac.at. |
المصدر: | Annals of surgical oncology [Ann Surg Oncol] 2020 May; Vol. 27 (5), pp. 1700-1707. Date of Electronic Publication: 2019 Dec 23. |
نوع المنشور: | Journal Article; Multicenter Study |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994- |
مواضيع طبية MeSH: | Chemotherapy, Adjuvant* , Margins of Excision* , Mastectomy, Segmental*, Breast Neoplasms/*therapy , Neoplasm Recurrence, Local/*diagnosis, Adult ; Aged ; Aged, 80 and over ; Austria/epidemiology ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Combined Modality Therapy ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Neoplasm Staging ; Preoperative Care ; Prognosis ; Retrospective Studies ; Survival Analysis ; Young Adult |
مستخلص: | Background: While "no tumour on ink" is an accepted margin width for R Methods: We retrospectively analysed data of 406 women with invasive breast cancer, treated with NAC and breast-conserving therapy between 1994 and 2014 in two certified Austrian breast health centres. We compared R ≤ 1 mm, R > 1 mm and RX (pCR) for local recurrence-free survival (LRFS), disease-free survival (DFS) and overall survival (OS). Results: After a median follow-up of 84.3 months, the 5-year LRFS (R ≤ 1 mm: 94.2%, R > 1 mm: 90.6%, RX: 95.0%; p = 0.940), the 5-year DFS (R ≤ 1 mm: 71.9%, R > 1 mm: 74.1%, RX: 87.2%; p = 0.245) and the 5-year OS (R ≤ 1 mm: 85.1%, R > 1 mm: 88.0%, RX: 96.4%; p = 0.236) did not differ significantly between narrow, wide, nor RX resections. Regarding DFS and OS, a negative nodal status reduced the hazard ratio significantly. Conclusion: There is no significant difference in LRFS, DFS and OS comparing close, wide or unknown margins after pCR. We suggest that resection in new margins after NAC is safe according to "no tumour on ink". Resection of the clipped area in cases of pCR is emphasized. |
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تواريخ الأحداث: | Date Created: 20191225 Date Completed: 20210111 Latest Revision: 20210111 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7138765 |
DOI: | 10.1245/s10434-019-08089-x |
PMID: | 31873929 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1534-4681 |
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DOI: | 10.1245/s10434-019-08089-x |