دورية أكاديمية
The landscape of eukaryotic mRNPs.
| العنوان: | The landscape of eukaryotic mRNPs. |
|---|---|
| المؤلفون: | Khong A; Department of Biochemistry and Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado 80303, USA., Parker R; Department of Biochemistry and Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, Colorado 80303, USA. |
| المصدر: | RNA (New York, N.Y.) [RNA] 2020 Mar; Vol. 26 (3), pp. 229-239. Date of Electronic Publication: 2019 Dec 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press Original Publication: New York, NY : Cambridge University Press, c1995- |
| مواضيع طبية MeSH: | RNA, Messenger/*genetics , RNA-Binding Proteins/*genetics , Ribonucleoproteins/*genetics , Ribosomes/*genetics, Cell Nucleus/genetics ; Eukaryota/genetics ; Nucleic Acid Conformation ; RNA, Messenger/ultrastructure ; RNA-Binding Proteins/ultrastructure ; Ribonucleoproteins/biosynthesis |
| مستخلص: | The proper regulation of mRNA processing, localization, translation, and degradation occurs on mRNPs. However, the global principles of mRNP organization are poorly understood. We utilize the limited, but existing, information available to present a speculative synthesis of mRNP organization with the following key points. First, mRNPs form a compacted structure due to the inherent folding of RNA. Second, the ribosome is the principal mechanism by which mRNA regions are partially decompacted. Third, mRNPs are 50%-80% protein by weight, consistent with proteins modulating mRNP organization, but also suggesting the majority of mRNA sequences are not directly interacting with RNA-binding proteins. Finally, the ratio of mRNA-binding proteins to mRNAs is higher in the nucleus to allow effective RNA processing and limit the potential for nuclear RNA based aggregation. This synthesis of mRNP understanding provides a model for mRNP biogenesis, structure, and regulation with multiple implications. (© 2020 Khong and Parker; Published by Cold Spring Harbor Laboratory Press for the RNA Society.) |
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| المشرفين على المادة: | 0 (RNA, Messenger) 0 (RNA-Binding Proteins) 0 (Ribonucleoproteins) 0 (messenger ribonucleoprotein) |
| تواريخ الأحداث: | Date Created: 20191228 Date Completed: 20200619 Latest Revision: 20210302 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7025503 |
| DOI: | 10.1261/rna.073601.119 |
| PMID: | 31879280 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1469-9001 |
|---|---|
| DOI: | 10.1261/rna.073601.119 |