دورية أكاديمية
Novel N,N-dimethylbarbituric-pyridinium derivatives as potent urease inhibitors: Synthesis, in vitro, and in silico studies.
العنوان: | Novel N,N-dimethylbarbituric-pyridinium derivatives as potent urease inhibitors: Synthesis, in vitro, and in silico studies. |
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المؤلفون: | Biglar M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Mirzazadeh R; Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran., Asadi M; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center, Tehran University of Medical Sciences, Tehran, Iran., Sepehri S; Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran., Valizadeh Y; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Sarrafi Y; Faculty of Chemistry, University of Mazandaran, Babolsar, Iran., Amanlou M; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Research Center, Tehran University of Medical Sciences, Tehran, Iran., Larijani B; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Mohammadi-Khanaposhtani M; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address: m.mohammadi-khana@mubabol.ac.ir., Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: momahdavi@tums.ac.ir. |
المصدر: | Bioorganic chemistry [Bioorg Chem] 2020 Jan; Vol. 95, pp. 103529. Date of Electronic Publication: 2019 Dec 20. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
مواضيع طبية MeSH: | Barbiturates/*chemistry , Enzyme Inhibitors/*chemical synthesis , Enzyme Inhibitors/*pharmacology , Pyridines/*chemistry , Urease/*antagonists & inhibitors, Barbiturates/pharmacology ; Biological Availability ; Computer Simulation ; Enzyme Inhibitors/pharmacokinetics ; Helicobacter pylori/enzymology ; In Vitro Techniques ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Molecular Structure ; Pyridines/pharmacology ; Spectrum Analysis/methods |
مستخلص: | A new series of N,N-dimethylbarbituric-pyridinium derivatives 7a-n was synthesized and evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds (IC Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2019. Published by Elsevier Inc.) |
فهرسة مساهمة: | Keywords: Barbituric acid; Helicobacter pylori; Molecular docking; N,N-dimethylbarbituric; Urease inhibitor |
المشرفين على المادة: | 0 (Barbiturates) 0 (Enzyme Inhibitors) 0 (Pyridines) EC 3.5.1.5 (Urease) |
تواريخ الأحداث: | Date Created: 20191230 Date Completed: 20210308 Latest Revision: 20210308 |
رمز التحديث: | 20240513 |
DOI: | 10.1016/j.bioorg.2019.103529 |
PMID: | 31884139 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2120 |
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DOI: | 10.1016/j.bioorg.2019.103529 |