دورية أكاديمية
أعرض في EDS

miR-147a suppresses the metastasis of non-small-cell lung cancer by targeting CCL5 .

التفاصيل البيبلوغرافية
العنوان: miR-147a suppresses the metastasis of non-small-cell lung cancer by targeting CCL5 .
المؤلفون: Lu Y; Nursing Department, Qilu Hospital of Shandong University, Jinan, Shandong, China., Luan XR; Nursing Department, Qilu Hospital of Shandong University, Jinan, Shandong, China.
المصدر: The Journal of international medical research [J Int Med Res] 2020 Apr; Vol. 48 (4), pp. 300060519883098. Date of Electronic Publication: 2019 Dec 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Nov. 2012- : London : Sage Publications
Original Publication: Northampton, Eng., Cambridge Medical Publications ltd.
مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/genetics , Chemokine CCL5* , Lung Neoplasms*/genetics , MicroRNAs*/genetics, Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Humans ; Mice ; Neoplasm Transplantation
مستخلص: Objective: MicroRNA (miR)-147a acts as an inhibitory miRNA in many cancers. However, its potential roles in non-small-cell lung cancer (NSCLC) remain unclear.
Methods: Levels of miR-147a and C-C motif chemokine ligand 5 (CCL5) were measured using a quantitative real-time PCR assay. Cell growth, migration, and invasion of NSCLC cells were assessed by colony formation, wound healing, and Transwell invasion assays, respectively. The role of miR-147a in the growth and metastatic ability of NSCLC in vivo was detected using a xenograft model and experimental lung metastasis model.
Results: miR-147a was downregulated in NSCLC cell lines as well as in tissues. Gain-of-function and loss-of-function analyses demonstrated that upregulation of miR-147a decreased the aggressiveness of NSCLC cells in vitro . In addition, CCL5 was identified as a target of miR-147a. We also demonstrated the effect of miR-147a in the progression of NSCLC cells via targeting CCL5. Finally, the in vivo mouse xenograft model showed that miR-147a inhibited progression of NSCLC cells.
Conclusions: Overall, expression of miR-147a was downregulated in NSCLC. Importantly, upregulation of miR-147a suppressed the growth and metastasis of NSCLC cells in vivo by targeting CCL5.
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فهرسة مساهمة: Keywords: C-C motif chemokine ligand 5; CCL5; NSCLC; invasion; metastasis; miR-147a; migration; non-small-cell lung cancer
المشرفين على المادة: 0 (CCL5 protein, human)
0 (Chemokine CCL5)
0 (MIRN147 microRNA, human)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20191231 Date Completed: 20210514 Latest Revision: 20220531
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7607764
DOI: 10.1177/0300060519883098
PMID: 31884861
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-2300
DOI:10.1177/0300060519883098