دورية أكاديمية
أعرض في EDS

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally.

التفاصيل البيبلوغرافية
العنوان: Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally.
المؤلفون: Mouro VGS; Department of General Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil., Martins ALP; Department of General Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil., Silva J; Department of General Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil., Menezes TP; Department of General Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil., Gomes MLM; Department of Structural Biology, Federal University of Triângulo Mineiro, Uberaba, MG 38025-180, Brazil., Oliveira JA; Department of General Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil., Melo FCSA; Department of Animal Biology, Federal University of Viçosa, Viçosa, 36570-900 MG, Brazil., Matta SLP; Department of General Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil.; Department of Animal Biology, Federal University of Viçosa, Viçosa, 36570-900 MG, Brazil.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2019 Nov 25; Vol. 2019, pp. 3429635. Date of Electronic Publication: 2019 Nov 25 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Cadmium Chloride/*toxicity , Testis/*drug effects, Administration, Oral ; Animals ; Injections, Intraperitoneal ; Male ; Malondialdehyde/metabolism ; Mice ; Nitric Oxide/metabolism ; Superoxide Dismutase/metabolism ; Testis/metabolism ; Testis/pathology ; Testosterone/blood
مستخلص: The toxic effects of cadmium (Cd) on reproductive parameters are widely described in the literature. Experimental models often make use of the intraperitoneal route ( i.p. ), although human intoxication occurs preferentially by the oral route and can be continuous. However, little is known about the effect of Cd administration routes on the testicular structure. Thus, this study investigated the testicular impact of Cd exposure comparing both i.p. and oral routes, both single dose (SD), in addition to the oral route in fractional doses (FD). Swiss adult male mice received CdCl 2 1.5 mg/kg i.p. , 30 mg/kg oral SD, and 4.28 mg/kg oral FD for 7 consecutive days. The Cd bioaccumulation was observed in all routes, mainly in the oral FD route. The concentrations of testicular Ca and Cu decreased in all animals exposed to Cd, while Zn and Mn decreased only in the i.p. route. Testicular SOD activity was reduced in both routes of oral administration, while CAT increased in the i.p. route, and GST increased in all animals exposed to Cd. Changes in the tubular parameters and cell viability were observed in both routes of Cd administration but were more intense in the oral route, mainly in the FD. Serum testosterone concentration was reduced in both routes of oral administration. Tubular damage, such as the vacuolization of the seminiferous epithelium, germ cell detachment, and seminiferous tubule degeneration, occurred in all groups exposed to Cd. Therefore, the oral Cd administration presented greater potential to promote testicular damage, mainly when the metal was given in a fractionated way.
Competing Interests: The authors indicate no potential conflicts of interest.
(Copyright © 2019 Viviane G. S. Mouro et al.)
References: Food Chem Toxicol. 2013 May;55:526-32. (PMID: 23395783)
Front Pharmacol. 2017 Jan 10;7:537. (PMID: 28119612)
Biochim Biophys Acta. 1999 Aug 12;1451(1):93-100. (PMID: 10446391)
Methods Enzymol. 1978;52:302-10. (PMID: 672633)
Circulation. 2000 Jan 4-11;101(1):33-9. (PMID: 10618301)
Reprod Toxicol. 2018 Jun;78:130-140. (PMID: 29702248)
Environ Toxicol Pharmacol. 2019 Apr;67:87-93. (PMID: 30769281)
Hum Exp Toxicol. 2017 Oct;36(10):1039-1048. (PMID: 27872163)
Food Chem Toxicol. 2015 Dec;86:25-33. (PMID: 26385724)
Exp Toxicol Pathol. 2014 Sep;66(7):293-300. (PMID: 24813645)
Clin Biochem. 2005 Nov;38(11):981-6. (PMID: 16150434)
Environ Toxicol Pharmacol. 2015 Jan;39(1):125-36. (PMID: 25499790)
Int J Exp Pathol. 2010 Apr;91(2):125-31. (PMID: 20015210)
Environ Health Perspect. 2010 Feb;118(2):182-90. (PMID: 20123617)
J Cell Sci. 2004 Feb 15;117(Pt 5):783-98. (PMID: 14734653)
Toxicology. 1999 Sep 10;137(1):13-22. (PMID: 10513996)
Sci Total Environ. 2015 Mar 1;508:37-45. (PMID: 25437951)
Biol Trace Elem Res. 2019 Jul;190(1):109-123. (PMID: 30291518)
Toxicol Sci. 2015 Nov;148(1):311-29. (PMID: 26424772)
Biol Trace Elem Res. 2019 Apr 27;:null. (PMID: 31030385)
Andrologia. 2017 Sep;49(7):null. (PMID: 27562125)
Cell. 2004 Apr 30;117(3):285-97. (PMID: 15109490)
Toxicology. 2004 Jul 15;200(1):29-38. (PMID: 15158561)
Saudi J Biol Sci. 2011 Jan;18(1):63-72. (PMID: 23961105)
Parasitol Res. 2016 Jul;115(7):2617-24. (PMID: 26987645)
Oxid Med Cell Longev. 2017;2017:3405089. (PMID: 29422988)
Oxid Med Cell Longev. 2008 Oct-Dec;1(1):15-24. (PMID: 19794904)
Reprod Toxicol. 2008 Jan;25(1):84-8. (PMID: 18065194)
Front Endocrinol (Lausanne). 2019 Jun 14;10:344. (PMID: 31258514)
Biol Trace Elem Res. 2018 Jun;183(2):314-324. (PMID: 28887675)
Semin Liver Dis. 2010 Aug;30(3):245-57. (PMID: 20665377)
Biol Trace Elem Res. 2016 May;171(1):176-84. (PMID: 26424218)
Toxicology. 1980;16(1):1-37. (PMID: 6250252)
Am J Pathol. 1995 Jan;146(1):3-15. (PMID: 7856735)
Biol Reprod. 1981 Apr;24(3):703-12. (PMID: 7236827)
Mutat Res. 2003 Dec 10;533(1-2):107-20. (PMID: 14643415)
Biol Trace Elem Res. 2016 Oct;173(2):362-71. (PMID: 26926909)
Am J Physiol Cell Physiol. 2005 Jan;288(1):C176-84. (PMID: 15355847)
Biol Trace Elem Res. 2011 Jun;141(1-3):262-74. (PMID: 20495888)
Endocrinology. 2002 Mar;143(3):970-8. (PMID: 11861520)
Life Sci. 2017 Apr 15;175:23-30. (PMID: 28300594)
Biol Res. 2010;43(4):445-50. (PMID: 21526271)
Toxicol Lett. 2004 Aug 30;152(1):19-25. (PMID: 15294343)
Nitric Oxide. 2002 Mar;6(2):178-85. (PMID: 11890742)
J Trace Elem Med Biol. 2018 Jul;48:213-223. (PMID: 29773184)
Biochem Pharmacol. 2004 Nov 1;68(9):1845-55. (PMID: 15450950)
Toxicol Appl Pharmacol. 2018 Feb 15;341:106-113. (PMID: 29408041)
Toxicology. 2002 Sep 30;179(1-2):37-50. (PMID: 12204541)
Hormones. 1970;1(1):2-25. (PMID: 5527187)
Food Chem Toxicol. 2012 Mar;50(3-4):552-7. (PMID: 22240416)
J Biol Chem. 1974 Nov 25;249(22):7130-9. (PMID: 4436300)
J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713)
Biol Trace Elem Res. 2016 Mar;170(1):152-64. (PMID: 26224376)
Free Radic Res. 2019 Jul;53(7):791-799. (PMID: 31198069)
Biochimie. 2006 Nov;88(11):1807-14. (PMID: 16814917)
المشرفين على المادة: 31C4KY9ESH (Nitric Oxide)
3XMK78S47O (Testosterone)
4Y8F71G49Q (Malondialdehyde)
EC 1.15.1.1 (Superoxide Dismutase)
J6K4F9V3BA (Cadmium Chloride)
تواريخ الأحداث: Date Created: 20191231 Date Completed: 20200501 Latest Revision: 20200501
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6899267
DOI: 10.1155/2019/3429635
PMID: 31885783
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2019/3429635