دورية أكاديمية
Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis.
| العنوان: | Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis. |
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| المؤلفون: | Melo CM; School of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil. Electronic address: carol_mirtes@hotmail.com., Cardoso JF; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address: jee.ferreirac@gmail.com., Perassoli FB; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address: fernandaperasoli@yahoo.com.br., de Oliveira Neto AS; School of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil. Electronic address: arisoaresneto@gmail.com., Pinto LM; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address: moreiraluccas@gmail.com., de Freitas Marques MB; Chemistry Department, Federal Univesity of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: betanialf@hotmail.com., da Nova Mussel W; Chemistry Department, Federal Univesity of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: wdmussel@yahoo.com.br., Magalhães JT; School of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil. Electronic address: julimagaufsj@gmail.com., de Lima Moura SA; Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address: sandralmoura@gmail.com., de Freitas Araújo MG; School of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil. Electronic address: mgfaraujo@ufsj.edu.br., Da Silva GR; School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address: giselersilva@ufop.edu.br. |
| المصدر: | Carbohydrate polymers [Carbohydr Polym] 2020 Feb 15; Vol. 230, pp. 115608. Date of Electronic Publication: 2019 Nov 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Publication: <1992-> : Barking : Elsevier Applied Science Publishers Original Publication: London [Eng.] : Applied Science Publishers, c1981- |
| مستخلص: | The treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC. (Copyright © 2019 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amphotericin B; Amphotericin B-loaded Eudragit RL100 nanoparticles coated with Hyaluronic Acid; Chloramphenicol; Chloroform; Copolymer of poly(ethylacrylate, methyl-methacrylate, and chloro trimethyl-ammonioethyl methacrylate); Cyclophosphamide; Dibasic sodium phosphate dodecahydrate; Estradiol cypionate; Eudragit RL100; Hyaluronic acid; Hyaluronic acid sodium salt; Methanol; Phosphoric acid; Polyoxyethylenesorbitan monooleate; Potassium phosphate monobasic; Sodium hydroxide; Vulvovaginal Candidiasis |
| تواريخ الأحداث: | Date Created: 20200101 Date Completed: 20200102 Latest Revision: 20200102 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.carbpol.2019.115608 |
| PMID: | 31887870 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1344 |
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| DOI: | 10.1016/j.carbpol.2019.115608 |