دورية أكاديمية
Design and synthesis of VEGFR-2 inhibitors based on oleanolic acid moiety.
| العنوان: | Design and synthesis of VEGFR-2 inhibitors based on oleanolic acid moiety. |
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| المؤلفون: | Song YL; Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China., Zhang PB; Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China., Tong RJ; Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China., Li L; Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China., Meng YQ; Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China. |
| المصدر: | Journal of Asian natural products research [J Asian Nat Prod Res] 2021 Feb; Vol. 23 (2), pp. 176-188. Date of Electronic Publication: 2019 Dec 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Newark, N.J.?] : Harwood Academic Publishers, |
| مواضيع طبية MeSH: | Oleanolic Acid*/pharmacology, Cell Proliferation ; Drug Design ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/metabolism |
| مستخلص: | In this study, twenty-four oleanolic acid (OA) derivatives were rationally designed based on molecule docking studies and their VEGFR-2 inhibitory activities were tested by Homogeneous time-resolved fluorescence (HTRF) method in vitro . All of the synthesized compounds were identified as new compounds, and the structures of these compounds were determined by 1 H-NMR and ESI-MS. In the screening for VEGFR-2 inhibitors, compounds I |
| فهرسة مساهمة: | Keywords: Oleanolic acid derivative; VEGFR-2 inhibitor; molecular docking |
| المشرفين على المادة: | 6SMK8R7TGJ (Oleanolic Acid) EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2) |
| تواريخ الأحداث: | Date Created: 20200101 Date Completed: 20210205 Latest Revision: 20210205 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/10286020.2019.1706500 |
| PMID: | 31888388 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1477-2213 |
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| DOI: | 10.1080/10286020.2019.1706500 |