دورية أكاديمية
Effects of chlorothalonil on the antioxidant defense system of mussels Perna perna.
| العنوان: | Effects of chlorothalonil on the antioxidant defense system of mussels Perna perna. |
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| المؤلفون: | Guerreiro ADS; Programa de Pós-Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, ICB, Universidade Federal do Rio Grande - FURG, 96203-900, Rio Grande, RS, Brazil. Electronic address: amandahg@gmail.com., Abreu FEL; Programa de Pós-Graduação em Oceanologia, Instituto de Oceanografia, IO, Universidade Federal do Rio Grande - FURG, 96203-900, Rio Grande, RS, Brazil., Fillmann G; Programa de Pós-Graduação em Oceanologia, Instituto de Oceanografia, IO, Universidade Federal do Rio Grande - FURG, 96203-900, Rio Grande, RS, Brazil., Sandrini JZ; Programa de Pós-Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, ICB, Universidade Federal do Rio Grande - FURG, 96203-900, Rio Grande, RS, Brazil. |
| المصدر: | Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Mar 01; Vol. 190, pp. 110119. Date of Electronic Publication: 2019 Dec 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Netherlands : Elsevier |
| مواضيع طبية MeSH: | Antioxidants/*metabolism , Fungicides, Industrial/*toxicity , Nitriles/*toxicity , Perna/*physiology, Animals ; Catalase/metabolism ; Fungicides, Industrial/metabolism ; Gills/drug effects ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Glutathione Reductase/metabolism ; Glutathione Transferase/metabolism ; Lipid Peroxidation/drug effects ; Perna/drug effects ; Superoxide Dismutase/metabolism |
| مستخلص: | Chlorothalonil is an effective fungicide used in agriculture and formulations of antifouling paints, which use and possible toxicity has been generating great concern. Thus, the present study investigated the effects of chlorothalonil on the antioxidant defense system (ADS) of the mussel Perna perna. The ADS was evaluated in gills and digestive gland after 24 h and 96 h of exposure to environmental relevant levels of chlorothalonil (0.1 and 10 μg/L). The activity of the enzymes superoxide dismutase (SOD), catalase (CAT), glutamate cysteine-ligase (GCL) and glutathione S-transferase (GST), levels of non-enzymatic defenses, represented by glutathione (GSH), and lipoperoxidation (LPO) and protein carbonyls (PCO) were evaluated. Results indicated that exposure to chlorothalonil is affecting the ADS in both tissues. While the activity of SOD increased and GST and GSH were not altered in gills, they decreased in digestive gland after 24 h of exposure to 10 μg/L of chlorothalonil. The contrasting results indicate that gills and digestive gland presented different patterns of responses after exposure to chlorothalonil. Moreover, a tissue-specific response to chlorothalonil was observed. Gills could be acting as the first line of defense, presenting higher enzymatic levels with minor effects on the parameters analyzed. On the other hand, digestive gland, with lower levels of antioxidant defenses, was the most affect organ by chlorothalonil. It also should be highlighted that the fungicide reduced the glutathione metabolism in the digestive gland, which can lead to an imbalance of the redox state within the cells of animals. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| التعليقات: | Erratum in: Ecotoxicol Environ Saf. 2020 Sep 15;201:110814. (PMID: 32485492) |
| فهرسة مساهمة: | Keywords: Antifouling biocides; Antioxidant enzymes; Biomarker; Bivalve; Oxidative stress; Toxicity |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Fungicides, Industrial) 0 (Nitriles) EC 1.11.1.6 (Catalase) EC 1.11.1.9 (Glutathione Peroxidase) EC 1.15.1.1 (Superoxide Dismutase) EC 1.8.1.7 (Glutathione Reductase) EC 2.5.1.18 (Glutathione Transferase) GAN16C9B8O (Glutathione) J718M71A7A (tetrachloroisophthalonitrile) |
| تواريخ الأحداث: | Date Created: 20200101 Date Completed: 20200327 Latest Revision: 20200327 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ecoenv.2019.110119 |
| PMID: | 31891835 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2414 |
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| DOI: | 10.1016/j.ecoenv.2019.110119 |