دورية أكاديمية
Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice.
| العنوان: | Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice. |
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| المؤلفون: | Blossom SJ; Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Research Institute, Little Rock, AR 72202, USA. blossomsarah@uams.edu., Melnyk SB, Simmen FA |
| المصدر: | Environmental science. Processes & impacts [Environ Sci Process Impacts] 2020 Mar 01; Vol. 22 (3), pp. 583-594. Date of Electronic Publication: 2020 Jan 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101601576 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2050-7895 (Electronic) Linking ISSN: 20507887 NLM ISO Abbreviation: Environ Sci Process Impacts Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Epigenesis, Genetic* , Trichloroethylene*, Animals ; Biomarkers ; Cerebellum ; Diet, High-Fat ; Female ; Male ; Mice ; Pregnancy |
| مستخلص: | Trichloroethylene (TCE) is an environmental contaminant associated with immune-mediated inflammatory disorders and neurotoxicity. Based on known negative effects of developmental overnutrition on neurodevelopment, we hypothesized that developmental exposure to high fat diet (HFD) consisting of 40% kcal fat would enhance neurotoxicity of low-level (6 μg per kg per day) TCE exposure in offspring over either stressor alone. Male offspring were evaluated at ∼6 weeks of age after exposure beginning 4 weeks preconception in the dams until weaning. TCE, whether used as a single exposure or together with HFD, appeared to be more robust than HFD alone in altering one-carbon metabolites involved in glutathione redox homeostasis and methylation capacity. In contrast, opposing effects of expression of key enzymes related to DNA methylation related to HFD and TCE exposure were observed. The mice generated unique patterns of anti-brain antibodies detected by western blotting attributable to both TCE and HFD. Taken together, developmental exposure to TCE and/or HFD appear to act in complex ways to alter brain biomarkers in offspring. |
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| معلومات مُعتمدة: | K02 ES024387 United States ES NIEHS NIH HHS; UL1 RR029884 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 0 (Biomarkers) 290YE8AR51 (Trichloroethylene) |
| تواريخ الأحداث: | Date Created: 20200103 Date Completed: 20200731 Latest Revision: 20200731 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7350281 |
| DOI: | 10.1039/c9em00514e |
| PMID: | 31894794 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2050-7895 |
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| DOI: | 10.1039/c9em00514e |