دورية أكاديمية
Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells.
| العنوان: | Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells. |
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| المؤلفون: | Romera-Hernández M; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Aparicio-Domingo P; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Papazian N; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Karrich JJ; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Cornelissen F; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Hoogenboezem RM; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Samsom JN; Department of Pediatrics, Division of Gastroenterology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands., Cupedo T; Department of Hematology, Erasmus University Medical Center, 3000CA Rotterdam, the Netherlands. Electronic address: t.cupedo@erasmusmc.nl. |
| المصدر: | Cell reports [Cell Rep] 2020 Jan 07; Vol. 30 (1), pp. 37-45.e3. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Immunity, Innate* , Wound Healing*, Adaptor Proteins, Signal Transducing/*metabolism , Cell Cycle Proteins/*metabolism , Intestines/*immunology , Intestines/*pathology , Lymphocytes/*pathology, Animals ; Cell Differentiation ; Cell Proliferation ; Cytokine Receptor gp130/metabolism ; Enzyme Activation ; Interleukins/metabolism ; Mice, Inbred C57BL ; Protein Multimerization ; Regeneration ; Signal Transduction ; Stem Cells/pathology ; YAP-Signaling Proteins ; src-Family Kinases/metabolism ; Interleukin-22 |
| مستخلص: | Tissue repair requires temporal control of progenitor cell proliferation and differentiation to replenish damaged cells. In response to acute insult, group 3 innate lymphoid cells (ILC3s) regulate intestinal stem cell maintenance and subsequent tissue repair. ILC3-derived IL-22 is important for stem cell protection, but the mechanisms of ILC3-driven tissue regeneration remain incompletely defined. Here we report that ILC3-driven epithelial proliferation and tissue regeneration are independent of IL-22. In contrast, ILC3s amplify the magnitude of Hippo-Yap1 signaling in intestinal crypt cells, ensuring adequate initiation of tissue repair and preventing excessive pathology. Mechanistically, ILC3-driven tissue repair is Stat3 independent, but it involves activation of Src family kinases. Our findings reveal that ILC3-driven intestinal repair entails distinct transcriptional networks to control stem cell maintenance and epithelial regeneration, which implies that tissue repair and crypt proliferation can be influenced by targeting innate immune cells independent of the well-established effects of IL-22. (Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: IL-22; YAP1; epithelial stem cell; innate lymphoid cells; intestine; tissue damage |
| المشرفين على المادة: | 0 (Adaptor Proteins, Signal Transducing) 0 (Cell Cycle Proteins) 0 (Il6st protein, mouse) 0 (Interleukins) 0 (YAP-Signaling Proteins) 0 (Yap1 protein, mouse) 133483-10-0 (Cytokine Receptor gp130) EC 2.7.10.2 (src-Family Kinases) |
| تواريخ الأحداث: | Date Created: 20200109 Date Completed: 20210106 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.celrep.2019.11.115 |
| PMID: | 31914395 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2019.11.115 |