دورية أكاديمية
أعرض في EDS

Aurora B-dependent Ndc80 degradation regulates kinetochore composition in meiosis.

التفاصيل البيبلوغرافية
العنوان: Aurora B-dependent Ndc80 degradation regulates kinetochore composition in meiosis.
المؤلفون: Chen J; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA., Liao A; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA., Powers EN; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA., Liao H; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA., Kohlstaedt LA; UC Berkeley QB3 Proteomics Facility, University of California at Berkeley, Berkeley, California 94720, USA., Evans R; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Holly RM; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA., Kim JK; Department of Biology, Columbia University, New York City, New York 10027, USA., Jovanovic M; Department of Biology, Columbia University, New York City, New York 10027, USA., Ünal E; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA.
المصدر: Genes & development [Genes Dev] 2020 Feb 01; Vol. 34 (3-4), pp. 209-225. Date of Electronic Publication: 2020 Jan 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE
أسماء مطبوعة: Publication: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press
Original Publication: [Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory in association with the Genetical Society of Great Britain, [c1987-
مواضيع طبية MeSH: Aurora Kinase B/*metabolism , Kinetochores/*metabolism , Meiosis/*physiology , Nuclear Proteins/*metabolism , Saccharomyces cerevisiae/*metabolism , Saccharomyces cerevisiae Proteins/*metabolism, Microtubules/metabolism ; Proteolysis
مستخلص: The kinetochore complex is a conserved machinery that connects chromosomes to spindle microtubules. During meiosis, the kinetochore is restructured to accommodate a specialized chromosome segregation pattern. In budding yeast, meiotic kinetochore remodeling is mediated by the temporal changes in the abundance of a single subunit called Ndc80. We previously described the regulatory events that control the timely synthesis of Ndc80. Here, we report that Ndc80 turnover is also tightly regulated in meiosis: Ndc80 degradation is active in meiotic prophase, but not in metaphase I. Ndc80 degradation depends on the ubiquitin ligase APC Ama1 and is mediated by the proteasome. Importantly, Aurora B-dependent Ndc80 phosphorylation, a mark that has been previously implicated in correcting erroneous microtubule-kinetochore attachments, is essential for Ndc80 degradation in a microtubule-independent manner. The N terminus of Ndc80, including a 27-residue sequence and Aurora B phosphorylation sites, is both necessary and sufficient for kinetochore protein degradation. Finally, defects in Ndc80 turnover predispose meiotic cells to chromosome mis-segregation. Our study elucidates the mechanism by which meiotic cells modulate their kinetochore composition through regulated Ndc80 degradation, and demonstrates that Aurora B-dependent regulation of kinetochores extends beyond altering microtubule attachments.
(© 2020 Chen et al.; Published by Cold Spring Harbor Laboratory Press.)
التعليقات: Comment in: Genes Dev. 2020 Feb 1;34(3-4):147-148. (PMID: 32015052)
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معلومات مُعتمدة: DP2 AG055946 United States AG NIA NIH HHS; R35 GM128802 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: APC; Aurora B; Ndc80; chromosome; kinetochore; meiosis; proteolysis
المشرفين على المادة: 0 (NDC80 protein, S cerevisiae)
0 (Nuclear Proteins)
0 (Saccharomyces cerevisiae Proteins)
EC 2.7.11.1 (Aurora Kinase B)
تواريخ الأحداث: Date Created: 20200111 Date Completed: 20200213 Latest Revision: 20201220
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7000919
DOI: 10.1101/gad.333997.119
PMID: 31919192
قاعدة البيانات: MEDLINE
الوصف
تدمد:1549-5477
DOI:10.1101/gad.333997.119