دورية أكاديمية
High-intensity interval training induced PGC-1∝ and AdipoR1 gene expressions and improved insulin sensitivity in obese individuals.
| العنوان: | High-intensity interval training induced PGC-1∝ and AdipoR1 gene expressions and improved insulin sensitivity in obese individuals. |
|---|---|
| المؤلفون: | Asilah Za'don NH; Universiti Kebangsaan Malaysia, Faculty of Health Sciences, Center for Health and Applied Sciences, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia. arimifitri@ukm.edu.my., Amirul Farhana MK; University Selangor (UNISEL), Faculty of Engineering and Life Sciences, Department of Health Sciences, Shah Alam, Selangor Darul Ehsan, Malaysia., Farhanim I; Universiti Teknologi Mara (UiTM), Faculty of Sport Science & Recreation, Shah Alam, Selangor, Malaysia., Sharifah Izwan TO; University Selangor (UNISEL), Faculty of Engineering and Life Sciences, Department of Health Sciences, Shah Alam, Selangor Darul Ehsan, Malaysia., Appukutty M; Universiti Teknologi Mara (UiTM), Faculty of Sport Science & Recreation, Shah Alam, Selangor, Malaysia., Salim N; Universiti Teknologi Mara (UiTM), Faculty of Medicine, Institute of Medical Molecular Biotechnology, Shah Alam, Selangor, Malaysia., Farah NMF; Universiti Kebangsaan Malaysia, Faculty of Health Sciences, Center for Community Health, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia., Arimi Fitri ML; Universiti Kebangsaan Malaysia, Faculty of Health Sciences, Center for Healthy Ageing & Wellness, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia. |
| المصدر: | The Medical journal of Malaysia [Med J Malaysia] 2019 Dec; Vol. 74 (6), pp. 461-467. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Malaysian Medical Association Country of Publication: Malaysia NLM ID: 0361547 Publication Model: Print Cited Medium: Internet ISSN: 0300-5283 (Print) Linking ISSN: 03005283 NLM ISO Abbreviation: Med J Malaysia Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kuala Lumpur : Malaysian Medical Association |
| مواضيع طبية MeSH: | Body Mass Index* , Gene Expression Regulation*, Exercise/*physiology , High-Intensity Interval Training/*methods , Insulin Resistance/*physiology , Obesity/*rehabilitation , Receptors, Adiponectin/*genetics, Adult ; Blood Glucose/metabolism ; Female ; Humans ; Insulin/blood ; Male ; Obesity/blood ; Obesity/genetics ; Receptors, Adiponectin/biosynthesis ; Young Adult |
| مستخلص: | Introduction: High-intensity interval training (HIIT) has been found to improve cardiometabolic health outcome as compared to moderate-intensity continuous exercise. However, there is still limited data on the benefits of HIIT on the expression of regulatory proteins that are linked to skeletal muscle metabolism and insulin sensitivity in obese adults. This study investigated the effects of HIIT intervention on expressions of peroxisome proliferatoractivated receptor-γ coactivator 1-∝ (PGC-1∝) and adiponectin receptor-1 (AdipoR1), insulin sensitivity (HOMAIR index), and body composition in overweight/obese individuals. Methods: Fifty overweight/obese individuals aged 22-29 years were assigned to either no-exercise control (n=25) or HIIT (n=25) group. The HIIT group underwent a 12-week intervention, three days/week, with intensity of 65-80% of age-based maximum heart rate. Anthropometric measurements, homeostatic model of insulin resistance (HOMA-IR) and gene expression analysis were conducted at baseline and post intervention. Results: Significant time-by-group interactions (p<0.001) were found for body weight, BMI, waist circumference and body fat percentage. The HIIT group had lower body weight (2.3%, p<0.001), BMI (2.7%, p<0.001), waist circumference (2.4%, p<0.001) and body fat percentage (4.3%, p<0.001) post intervention. Compared to baseline, expressions of PGC-1∝ and AdipoR1 were increased by approximately three-fold (p=0.019) and two-fold (p=0.003) respectively, along with improved insulin sensitivity (33%, p=0.019) in the HIIT group. Conclusion: Findings suggest that HIIT possibly improved insulin sensitivity through modulation of PGC-1∝ and AdipoR1. This study also showed that improved metabolic responses can occur despite modest reduction in body weight in overweight/obese individuals undergoing HIIT intervention. |
| المشرفين على المادة: | 0 (ADIPOR1 protein, human) 0 (Blood Glucose) 0 (Insulin) 0 (Receptors, Adiponectin) |
| تواريخ الأحداث: | Date Created: 20200114 Date Completed: 20200813 Latest Revision: 20200813 |
| رمز التحديث: | 20240628 |
| PMID: | 31929469 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-5283 |
|---|