دورية أكاديمية
أعرض في EDS

Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure.

التفاصيل البيبلوغرافية
العنوان: Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure.
المؤلفون: Seck MC; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal. mcseck203@yahoo.fr.; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal. mcseck203@yahoo.fr., Thwing J; Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, 30029, USA., Badiane AS; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Rogier E; Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, 30029, USA., Fall FB; Senegal National Malaria Control Programme, Dakar, Senegal., Ndiaye PI; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Diongue K; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Mbow M; Department of Immunology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal., Ndiaye M; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Diallo MA; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Gomis JF; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Mbaye A; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Ndiaye T; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Gaye A; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Sy M; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Déme AB; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Ndiaye YD; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal., Ndiaye D; Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal.; Laboratory of Parasitology, Aristide Le Dantec Teaching Hospital, Dakar, Senegal.
المصدر: Malaria journal [Malar J] 2020 Jan 13; Vol. 19 (1), pp. 15. Date of Electronic Publication: 2020 Jan 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Transients and Migrants*, Antibodies, Protozoan/*blood , Immunoglobulin G/*blood , Malaria, Falciparum/*epidemiology , Plasmodium falciparum/*immunology, Adolescent ; Adult ; Aged ; Animals ; Anopheles/parasitology ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/immunology ; Male ; Microspheres ; Middle Aged ; Mosquito Vectors/parasitology ; Rain ; Seasons ; Senegal/epidemiology ; Seroepidemiologic Studies ; Young Adult
مستخلص: Background: Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activities, hosts Fulani, nomadic, pastoralists that spend the dry season in the south where malaria incidence is higher (150-450/1000 inhabitants) and return to the north with the first rains. Previous research demonstrated parasite prevalence of < 1% in this Fulani population upon return from the south, similar to that documented in the north in cross-sectional surveys.
Methods: A modified snowball sampling survey of nomadic pastoralists was conducted in five districts in northern Senegal during September and October 2014. Demographic information and dried blood spots were collected. Multiplex bead-based assays were used to assess antibody responses to merozoite surface protein (MSP-1 19 ) antigen of the four primary Plasmodium species, as well as circumsporozoite protein (CSP) and liver stage antigen (LSA-1) of Plasmodium falciparum.
Results: In the five study districts, 1472 individuals were enrolled, with a median age of 22 years (range 1 to 80 years). Thirty-two percent of subjects were under 14 years and 57% were male. The overall seroprevalence of P. falciparum MSP-1 19 , CSP and LSA-1 antibodies were 45, 12 and 5%, respectively. Plasmodium falciparum MSP-1 19 antibody responses increased significantly with age in all study areas, and were significantly higher among males. The highest seroprevalence to P. falciparum antigens was observed in the Kanel district (63%) and the lowest observed in Podor (28%). Low seroprevalence was observed for non-falciparum species in all the study sites: 0.4, 0.7 and 1.8%, respectively, for Plasmodium ovale, Plasmodium vivax and Plasmodium malariae MSP-1. Antibody responses to P. vivax were observed in all study sites except Kanel.
Conclusion: Prevalence of P. falciparum MSP-1 19 antibodies and increases by study participant age provided data for low levels of exposure among this transient nomadic population. In addition, antibody responses to P. falciparum short half-life markers (CSP and LSA-1) and non-falciparum species were low. Further investigations are needed to understand the exposure of the Fulani population to P. vivax.
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فهرسة مساهمة: Keywords: Antibodies; CSP; Fulani; LSA-1; MSP-119; Malaria; Plasmodium; Senegal
المشرفين على المادة: 0 (Antibodies, Protozoan)
0 (Immunoglobulin G)
تواريخ الأحداث: Date Created: 20200115 Date Completed: 20200817 Latest Revision: 20200817
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6958760
DOI: 10.1186/s12936-020-3114-2
PMID: 31931834
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2875
DOI:10.1186/s12936-020-3114-2