دورية أكاديمية
Investigation on beneficial role of l-carnosine in neuroprotective mechanism of ischemic postconditioning in mice: possible role of histidine histamine pathway.
| العنوان: | Investigation on beneficial role of l-carnosine in neuroprotective mechanism of ischemic postconditioning in mice: possible role of histidine histamine pathway. |
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| المؤلفون: | Virdi JK; Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India., Bhanot A; Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India., Jaggi AS; Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India., Agarwal N; Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India. |
| المصدر: | The International journal of neuroscience [Int J Neurosci] 2020 Oct; Vol. 130 (10), pp. 983-998. Date of Electronic Publication: 2020 Feb 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, Gordon and Breach. |
| مواضيع طبية MeSH: | Ischemic Postconditioning*, Brain Ischemia/*metabolism , Brain Ischemia/*therapy , Carnosine/*pharmacology , Histamine/*metabolism , Histidine/*metabolism , Neuroprotective Agents/*pharmacology , Signal Transduction/*drug effects, Animals ; Brain Ischemia/drug therapy ; Carnosine/administration & dosage ; Histamine H2 Antagonists/pharmacology ; Male ; Maze Learning/physiology ; Mice ; Neuroprotective Agents/administration & dosage |
| مستخلص: | Objective: The present study was undertaken to investigate the possible role of histidine-histamine pathway in the neuroprotective effects produced by L-carnosine hand in hand with ischemic postconditioning in the animal model of cerebral ischemia. Methods: Cerebral ischemia was induced in swiss albino mice by performing BCCAO surgery. Morris water-maze test was utilized to assess the learning ability and memory of the animals. The whole brain acetylcholinesterase (AChE) activity, TBARS, GSH levels and MPO activity were evaluated as the biochemical parameters. For histopathological evaluation of the cerebral infarct size, TTC staining was employed. Results: Administration of L-carnosine (500 mg/kg, i.p.) successfully attenuated the manifestations of cerebral ischemia. Higher levels of AChE, TBARS, and MPO were observed in BCCAO treated animals, which were successfully attenuated by treatment with L-carnosine and ischemic postconditioning. Whereas administration of L-carnosine and ischemic postconditioning significantly increased the level of GSH in BCCAO treated animals. Moreover, treatment with ranitidine, an H Conclusion: It is concluded that L-carnosine exerts neuroprotective effect via involvement of histidine-histamine pathway since the beneficial effects of L-carnosine were abolished by the H |
| فهرسة مساهمة: | Keywords: l-carnosine; BCCAO; Cerebral ischemia; histidine-histamine pathway |
| المشرفين على المادة: | 0 (Histamine H2 Antagonists) 0 (Neuroprotective Agents) 4QD397987E (Histidine) 820484N8I3 (Histamine) 8HO6PVN24W (Carnosine) |
| تواريخ الأحداث: | Date Created: 20200118 Date Completed: 20210706 Latest Revision: 20210706 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/00207454.2020.1715393 |
| PMID: | 31951767 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1563-5279 |
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| DOI: | 10.1080/00207454.2020.1715393 |