دورية أكاديمية
أعرض في EDS

Multidimensional Studies of Pancratium parvum Dalzell Against Acetylcholinesterase: A Potential Enzyme for Alzheimer's Management.

التفاصيل البيبلوغرافية
العنوان: Multidimensional Studies of Pancratium parvum Dalzell Against Acetylcholinesterase: A Potential Enzyme for Alzheimer's Management.
المؤلفون: Patil DN; Department of Biotechnology, Shivaji University, Kolhapur, India., Yadav SR; Department of Botany, Shivaji University, Kolhapur, India., Patil S; Department of Biotechnology, Shivaji University, Kolhapur, India., Bapat VA; Department of Biotechnology, Shivaji University, Kolhapur, India., Jadhav JP; Department of Biotechnology, Shivaji University, Kolhapur, India.; Department of Biochemistry, Shivaji University, Kolhapur, India.
المصدر: Journal of the American College of Nutrition [J Am Coll Nutr] 2020 Sep-Oct; Vol. 39 (7), pp. 601-618. Date of Electronic Publication: 2020 Jan 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American College of Nutrition Country of Publication: United States NLM ID: 8215879 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-1087 (Electronic) Linking ISSN: 07315724 NLM ISO Abbreviation: J Am Coll Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : American College of Nutrition
Original Publication: New York : Alan R. Liss, c1982-
مواضيع طبية MeSH: Alzheimer Disease*/drug therapy , Amaryllidaceae*/chemistry , Plant Extracts*/pharmacology, Acetylcholinesterase ; Antioxidants/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Humans
مستخلص: Objective: Pancratium L. (Amaryllidaceae J.St. Hil.) is a monocot genus with bulbous habitat and about 20 species worldwide have significant medicinal properties. The present envision aims to investigate the potential ability of Pancratium species for acetylcholinesterase (AChE) inhibition as a remedy for Alzheimer disease (AD). Different Pancratium species were screened for the inhibition of AChE enzyme from various localities across India. Prominent species was further studied for anti-inflammatory, antioxidant, metal chelating and UHPLC-QTOF-MS analysis. Methods: Nine different species collected across India were examined for AChE inhibition and for binding affinity studies using Surface Plasmon Resonance (SPR). Highest inhibition species was subjected to Response Surface Methodology (RSM) to accomplish the effective conditions for maximum extraction of phytomolecules in accordance with the inhibition of the AChE. Further, extract under optimized conditions were used to study anti-inflammatory, antioxidant, metal chelating and UHPLC-QTOF-MS analysis for tentative identification of phytomolecules. Results: Amongst different species collected, P. parvum Dalzell exhibited maximum inhibition 93.30 ± 1.71% with promising IC 50 20 ± 0.22 µg/ml value. In addition, binding affinity toward AChE and β plaques using SPR technique showed a higher binding response toward the enzyme. RSM study resulted that water extracts at 50 °C and 5.46 hours heating executed maximum inhibition. Other studies showed prominent anti-inflammatory and metal chelating ability with low antioxidant property. Conclusion: By using UHPLC-QTOF-MS compounds were tentatively identified for the concerned activities mentioned above. This work reports for accounting the detailed study of P. parvum and which can be further entailed for the treatment of various neurological disorders.
فهرسة مساهمة: Keywords: LCMS-QTOFMS; P. parvum; RSM; SPR; anti-Alzheimer’s drug; inhibitory activity
المشرفين على المادة: 0 (Antioxidants)
0 (Cholinesterase Inhibitors)
0 (Plant Extracts)
EC 3.1.1.7 (Acetylcholinesterase)
تواريخ الأحداث: Date Created: 20200118 Date Completed: 20211124 Latest Revision: 20220531
رمز التحديث: 20240628
DOI: 10.1080/07315724.2019.1709914
PMID: 31951787
قاعدة البيانات: MEDLINE
الوصف
تدمد:1541-1087
DOI:10.1080/07315724.2019.1709914