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Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves.

التفاصيل البيبلوغرافية
العنوان: Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves.
المؤلفون: Onoja SO; Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture Umudike, PMB 7267 Umuahia, Nigeria., Nnadi CO; Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka, 410001 Enugu State, Nigeria., Udem SC; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka 410001 Enugu State, Nigeria., Anaga AO; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka 410001 Enugu State, Nigeria.
المصدر: Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2020 Jun 01; Vol. 70 (2), pp. 215-226.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sciendo Country of Publication: Poland NLM ID: 9303678 Publication Model: Print Cited Medium: Internet ISSN: 1846-9558 (Electronic) Linking ISSN: 13300075 NLM ISO Abbreviation: Acta Pharm Subsets: MEDLINE
أسماء مطبوعة: Publication: Warsaw, Poland : Sciendo
Original Publication: Zagreb : Croatian Pharmaceutical Society, 1992-
مواضيع طبية MeSH: Antioxidants/*pharmacology , Diabetes Mellitus, Experimental/*drug therapy , Helianthus/*chemistry , Hypoglycemic Agents/*pharmacology , Lactones/*pharmacology , Plant Extracts/*pharmacology , Plant Leaves/*chemistry , Sesquiterpenes/*pharmacology, Animals ; Biphenyl Compounds/chemistry ; Disease Models, Animal ; Flavonoids/pharmacology ; Male ; Picrates/chemistry ; Plants, Medicinal/chemistry ; Rats ; Rats, Wistar
مستخلص: Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves. The heliangolide sesquiterpene lactone was isolated through a combination of solvent-solvent partitioning, column chromatography, thin layer chromatography and high-performance liquid chromatography techniques. The antioxidant activity of the compound was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays while the antidiabetic effects were investigated in alloxan-induced diabetic rats. The heliangolide derivative at the concentration of 954.2 µmol L-1 showed 23.7 % DPPH and 26 % nitric oxide radical inhibitions compared with 96.6 and 50.9 %, resp., displayed by the controls (2,271.2 µmol L-1). It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg-1 bm. The heliangolide derivative exhibited significant (p < 0.05) antioxidant and antidiabetic properties and provides a basis for further development of constituents of Helianthus annuus leaves for the management of such diseases.
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فهرسة مساهمة: Keywords: Helianthus annuus; antidiabetic; antioxidant; heliangolide derivative
المشرفين على المادة: 0 (Antioxidants)
0 (Biphenyl Compounds)
0 (Flavonoids)
0 (Hypoglycemic Agents)
0 (Lactones)
0 (Picrates)
0 (Plant Extracts)
0 (Sesquiterpenes)
DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
تواريخ الأحداث: Date Created: 20200120 Date Completed: 20200930 Latest Revision: 20230118
رمز التحديث: 20230120
DOI: 10.2478/acph-2020-0019
PMID: 31955145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1846-9558
DOI:10.2478/acph-2020-0019