دورية أكاديمية
أعرض في EDS

Reintroduction failure after negative food challenges in adults is common and mainly due to atypical symptoms.

التفاصيل البيبلوغرافية
العنوان: Reintroduction failure after negative food challenges in adults is common and mainly due to atypical symptoms.
المؤلفون: Versluis A; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands., Knulst AC; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands., van Erp FC; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands., Blankestijn MA; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands., Meijer Y; Department of Pediatric Pulmonology and Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands., Le TM; Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands., van Os-Medendorp H; Department of Health Care, Saxion University of Applied Sciences, Enschede, The Netherlands.
المصدر: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2020 Apr; Vol. 50 (4), pp. 479-486. Date of Electronic Publication: 2020 Feb 10.
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2222 (Electronic) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications, c1989-
مواضيع طبية MeSH: Quality of Life* , Surveys and Questionnaires*, Food/*adverse effects , Food Hypersensitivity/*therapy, Adolescent ; Adult ; Aftercare ; Aged ; Anxiety/etiology ; Anxiety/therapy ; Feeding Behavior ; Female ; Food Hypersensitivity/complications ; Humans ; Male ; Middle Aged ; Prospective Studies
مستخلص: Background: Reintroduction of a food after negative food challenge (FC) faces many obstacles. There are no studies available about this subject in adults.
Objective: To investigate the frequency, reasons and risk factors of reintroduction failure in adults.
Methods: In this prospective study, adult patients received standardized follow-up care after negative FCs including a reintroduction scheme and supportive telephone consultations. Data were collected by telephone interview (2 weeks after FC) and questionnaires (at baseline and 6 months after FC(s)): food habits questionnaire, State-Trait Anxiety Inventory, Food Allergy Quality of Life Questionnaire-Adult Form and Food Allergy Independent Measure. Frequency and reasons of reintroduction failure were analysed using descriptive statistics and risk factors with univariate analyses.
Results: Eighty patients were included with, in total, 113 negative FCs. Reintroduction failed on short-term (2 weeks after FC) in 20% (95% CI: 13%-28%). Common reasons were symptoms upon ingestion during the reintroduction scheme (50%) and no need to eat the food (23%). On the long-term (5-12 months after FC(s)), reintroduction failure increased to 40% (95% CI: 28%-53%). Common reasons were atypical symptoms after eating the food (59%) and fear for an allergic reaction (24%). Five risk factors for long-term reintroduction failure were found: if culprit food was not one of the 13 EU regulated allergens, reintroduction failure at short-term, atypical symptoms during FC, a lower quality of life and a higher state anxiety.
Conclusions and Clinical Relevance: Reintroduction failure after negative FCs in adults is common, increases over time, and is primarily due to atypical symptoms. This stresses the need for more patient-tailored care before and after negative food challenges.
(© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: food allergy; food challenge; reintroduction
تواريخ الأحداث: Date Created: 20200120 Date Completed: 20210610 Latest Revision: 20210610
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7187472
DOI: 10.1111/cea.13572
PMID: 31955473
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2222
DOI:10.1111/cea.13572