دورية أكاديمية
Connective Tissue Progenitor Analysis of Bone Marrow Aspirate Concentrate Harvested From the Body of the Ilium During Arthroscopic Acetabular Labral Repair.
| العنوان: | Connective Tissue Progenitor Analysis of Bone Marrow Aspirate Concentrate Harvested From the Body of the Ilium During Arthroscopic Acetabular Labral Repair. |
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| المؤلفون: | Nazal MR; Sports Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Partners Heath System, Boston, Massachusetts, U.S.A.. Electronic address: mnazal@mgh.harvard.edu., McCarthy MBR; Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, U.S.A., Mazzocca AD; Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut, U.S.A., Martin SD; Sports Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Partners Heath System, Boston, Massachusetts, U.S.A. |
| المصدر: | Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association [Arthroscopy] 2020 May; Vol. 36 (5), pp. 1311-1320. Date of Electronic Publication: 2020 Jan 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 8506498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-3231 (Electronic) Linking ISSN: 07498063 NLM ISO Abbreviation: Arthroscopy Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : W.B. Saunders Co. Original Publication: [New York, N.Y.] : Raven Press, [c1985- |
| مواضيع طبية MeSH: | Acetabulum/*surgery , Arthroscopy/*methods , Bone Marrow Cells/*cytology , Cartilage Diseases/*surgery , Cartilage, Articular/*surgery , Stem Cells/*cytology , Tissue and Organ Harvesting/*methods, Acetabulum/pathology ; Adult ; Cartilage Diseases/pathology ; Cartilage, Articular/pathology ; Cell Count ; Female ; Follow-Up Studies ; Humans ; Ilium ; Male ; Middle Aged ; Prospective Studies ; Young Adult |
| مستخلص: | Purpose: To evaluate the number and concentration of progenitors of the bone marrow aspirate (BMA) harvest from the body of the ilium in comparison with other established aspiration sites. Methods: The inclusion criteria consisted of primary hip arthroscopy for acetabular labral tear. BMA was performed by placing an aspiration needle into the body of ilium just proximal to the sourcil in 33 patients. The BMA was centrifuged and processed in the operating room, resulting in approximately 3 to 5 mL of bone marrow aspirate concentrate (BMAC). Samples of both BMA and BMAC sample were analyzed. Results: The cohort of 30 patients had a mean number of nucleated cells of 24.0 million nucleated cells/cc of BMA. The BMAC samples had a mean connective tissue progenitor (CTP) cell concentration of 879.3 stem cells/cc of BMAC, a mean CTP prevalence of 34.1 stem cells/million nucleated cells, and a mean number of days to form colonies of 2.97 days. All 4 metrics of CTP harvest did not vary significantly with age, body mass index, sex, or laterality. The nucleated cell count was significantly associated with both CTP prevalence, r 2 = 0.287 (P = .002), and CTP concentration, r 2 = 0.388 (P < .001). Conclusions: BMAC harvested from the body of the ilium during concurrent hip arthroscopy is a technically and biologically feasible option. Furthermore, the harvest site was found to have a CTP concentration that is similar or exceeds other published harvest sites. Finally, BMAC processing and application to areas of articular cartilage wear was performed efficiently and safely with no increase in morbidity or complications. Clinical Relevance: The body of the ilium is a reliable and rich source of CTP cells. This study may assist orthopaedic surgeons interested in performing biologic augmentation during hip surgery in determining a harvest site. (Copyright © 2020 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Arthroscopy. 2020 May;36(5):1321-1322. (PMID: 32370894) |
| تواريخ الأحداث: | Date Created: 20200121 Date Completed: 20201123 Latest Revision: 20201123 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/j.arthro.2019.11.125 |
| PMID: | 31958539 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1526-3231 |
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| DOI: | 10.1016/j.arthro.2019.11.125 |