دورية أكاديمية
Subclinical Hypothyroidism with TSH>7 mIU/l and≤10 mIU/l and Coronary Artery Disease.
| العنوان: | Subclinical Hypothyroidism with TSH>7 mIU/l and≤10 mIU/l and Coronary Artery Disease. |
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| المؤلفون: | Rosário PWS; Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Minas Gerais, Brazil., Calsolari MR; Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Minas Gerais, Brazil. |
| المصدر: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2020 Feb; Vol. 52 (2), pp. 85-88. Date of Electronic Publication: 2020 Jan 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 0177722 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-4286 (Electronic) Linking ISSN: 00185043 NLM ISO Abbreviation: Horm Metab Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Stuttgart, Thieme. |
| مواضيع طبية MeSH: | Coronary Artery Disease/*etiology , Hypothyroidism/*complications , Thyrotropin/*blood, Adult ; Aged ; Coronary Artery Disease/diagnosis ; Female ; Humans ; Hypothyroidism/blood ; Male ; Middle Aged ; Risk Factors |
| مستخلص: | The association of subclinical hypothyroidism (SCH) with increased cardiovascular risk is controversial when thyroid-stimulating hormone (TSH) concentration is<10 mIU/l, as well as its association with a higher coronary artery calcium score (CACS) in individuals with low cardiovascular risk. This study evaluated coronary artery disease (CAD) by CACS in asymptomatic, low-cardiovascular risk women with SCH and TSH>7 mIU/l and≤10 mIU/l untreated for 5 years after diagnosis. The CACS was obtained for two groups of women with low cardiovascular risk. Group A consisted of 32 women with mild SCH (TSH>7 mIU/l and≤10 mIU/l) who remained untreated for 5 years, and group B consisted of 32 euthyroid women matched for age and body mass index to group A. The CACS ranged from 0 to 350 (median 0, 25-75% interval: 0-10) in group A and from 0 to 280 (median 0, 25-75% interval: 0-0) in group B. Scores>0 and≥10 were significantly more frequent in group A (40.6 vs. 12.5% and 25 vs. 3.1%, respectively). A CACS≥100 was also more frequent in group A (18.75 vs. 3.1%), but the difference was not significant (p=0.1). The results of the study suggest that long-term SCH with TSH>7 mIU/l and ≤ 10 mIU/l is associated with a higher risk of CAD in individuals≤65 years, even in those with low cardiovascular risk. Competing Interests: The authors declare that they have no conflict of interest. (© Georg Thieme Verlag KG Stuttgart · New York.) |
| المشرفين على المادة: | 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20200121 Date Completed: 20201021 Latest Revision: 20201021 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1055/a-1083-6509 |
| PMID: | 31958872 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-4286 |
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| DOI: | 10.1055/a-1083-6509 |