دورية أكاديمية
Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment.
العنوان: | Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment. |
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المؤلفون: | Araújo TSL; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Oliveira TM; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Sousa NA; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Souza LKM; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Sousa FBM; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Oliveira AP; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Nicolau LAD; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., da Silva AAV; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Araújo AR; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Magalhães PJC; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Vasconcelos DFP; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Jonge HR; Department of Gastroenterology & Hepatology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands., Souza MHLP; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Silva DA; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Paula RCM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE 60451-970, Brazil., Medeiros JVR; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil. |
المصدر: | Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2020 Jan 18; Vol. 13 (1). Date of Electronic Publication: 2020 Jan 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c2004- |
مستخلص: | Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil's semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina . Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm -1 , 1368 cm -1 , and 1029 cm -1 , which relate to the vibration of O-H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 10 5 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli -induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases. |
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معلومات مُعتمدة: | Edital FAPEPI/SESAPI/MS/CNPq/PPSUS/N◦ 002/2016 Research Foundation for the State of Piauí - FAPEPI; EDITAL FAPEPI / MCTIC/ CNPq Nº 008/2018 FAPEPI-CNPQ (PROGRAMA DE APOIO A NÚCLEOS EMERGENTES DE PESQUISA - PRONEM) |
فهرسة مساهمة: | Keywords: Escherichia coli; Fabaceae; cholera; diarrhea; polysaccharide |
تواريخ الأحداث: | Date Created: 20200123 Latest Revision: 20200930 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7168896 |
DOI: | 10.3390/ph13010017 |
PMID: | 31963683 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1424-8247 |
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DOI: | 10.3390/ph13010017 |