دورية أكاديمية
أعرض في EDS

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment.

التفاصيل البيبلوغرافية
العنوان: Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment.
المؤلفون: Araújo TSL; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Oliveira TM; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Sousa NA; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Souza LKM; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Sousa FBM; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Oliveira AP; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Nicolau LAD; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., da Silva AAV; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Araújo AR; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Magalhães PJC; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Vasconcelos DFP; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., de Jonge HR; Department of Gastroenterology & Hepatology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands., Souza MHLP; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Silva DA; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil., Paula RCM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE 60451-970, Brazil., Medeiros JVR; The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, PI 64049-550, Brazil.; Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of the Parnaíba Delta, Parnaíba, PI 64202-020, Brazil.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2020 Jan 18; Vol. 13 (1). Date of Electronic Publication: 2020 Jan 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil's semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina . Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm -1 , 1368 cm -1 , and 1029 cm -1 , which relate to the vibration of O-H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 10 5 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli -induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.
References: Electrolyte Blood Press. 2010 Dec;8(2):82-6. (PMID: 21468201)
Prostaglandins. 1976 May;11(5):809-28. (PMID: 935512)
Biomed Pharmacother. 2018 Jan;97:1147-1154. (PMID: 29136953)
J Mol Biol. 1999 Dec 17;294(5):1257-69. (PMID: 10600383)
J Ethnopharmacol. 1998 Feb;60(1):85-9. (PMID: 9533436)
Adv Exp Med Biol. 1999;464:37-47. (PMID: 10335384)
Food Chem Toxicol. 2008 Mar;46(3):1048-54. (PMID: 18078702)
Int J Biol Macromol. 2020 May 1;150:1175-1183. (PMID: 31765749)
World J Gastroenterol. 2012 Jul 7;18(25):3207-14. (PMID: 22783044)
Nat Prod Res. 2016 Jun;30(11):1289-92. (PMID: 26158209)
Dig Dis Sci. 1993 Jun;38(6):977-95. (PMID: 8508715)
Phytother Res. 2006 Sep;20(9):717-24. (PMID: 16619336)
Acta Cir Bras. 2012 Oct;27(10):655-70. (PMID: 23033126)
Food Chem Toxicol. 2011 Sep;49(9):2222-8. (PMID: 21712063)
Evid Based Complement Alternat Med. 2014;2014:802696. (PMID: 25093029)
Lancet. 2013 Apr 20;381(9875):1405-1416. (PMID: 23582727)
Biochem Pharmacol. 1962 Mar;11:229-36. (PMID: 14005307)
J Bacteriol. 2015 May;197(10):1716-25. (PMID: 25733618)
Evid Based Complement Alternat Med. 2012;2012:364564. (PMID: 21949671)
Drug Des Devel Ther. 2016 Jan 28;10:483-507. (PMID: 26869768)
Toxins (Basel). 2015 Mar 20;7(3):974-96. (PMID: 25802972)
BMC Complement Altern Med. 2014 Feb 22;14:71. (PMID: 24559094)
BMC Complement Altern Med. 2014 Dec 02;14:460. (PMID: 25465058)
PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2674. (PMID: 24551253)
J Ethnopharmacol. 2012 Aug 30;143(1):81-90. (PMID: 22750452)
Pharmacogn Rev. 2011 Jul;5(10):147-54. (PMID: 22279372)
Physiol Rev. 1979 Jul;59(3):606-718. (PMID: 37533)
Phytother Res. 1999 Sep;13(6):468-73. (PMID: 10479755)
J Ethnobiol Ethnomed. 2006 Jan 18;2:6. (PMID: 16420708)
Int J Biol Macromol. 2016 May;86:865-75. (PMID: 26879913)
Antimicrob Agents Chemother. 2013 Sep;57(9):4373-80. (PMID: 23817372)
Evid Based Complement Alternat Med. 2018 Oct 4;2018:1360486. (PMID: 30402115)
J Agric Food Chem. 2009 Apr 22;57(8):3113-9. (PMID: 19290638)
Int J Biol Macromol. 2017 Apr;97:34-45. (PMID: 28064049)
Rev Saude Publica. 1995 Dec;29(6):428-33. (PMID: 8734966)
PLoS One. 2017 Dec 27;12(12):e0189263. (PMID: 29281656)
Inflamm Res. 2011 Dec;60(12):1121-30. (PMID: 21879365)
J Ethnopharmacol. 2015 Nov 4;174:299-307. (PMID: 26297843)
Carbohydr Polym. 2017 Feb 10;157:567-575. (PMID: 27987963)
Immunol Lett. 2003 Oct 31;89(2-3):175-85. (PMID: 14556976)
Clin Gastroenterol Hepatol. 2004 Mar;2(3):198-206. (PMID: 15017602)
Future Med Chem. 2013 May;5(7):781-98. (PMID: 23651092)
Pharmacol Rev. 1986 Dec;38(4):321-416. (PMID: 2432624)
J Ethnopharmacol. 2008 Feb 28;116(1):125-30. (PMID: 18164567)
Basic Clin Pharmacol Toxicol. 2016 Jun;118(6):440-8. (PMID: 26582552)
Biochemistry. 1999 May 4;38(18):5684-92. (PMID: 10231518)
Am J Physiol. 1984 Apr;246(4 Pt 1):G361-71. (PMID: 6547025)
Carbohydr Res. 2008 Oct 13;343(15):2589-94. (PMID: 18703180)
J Ethnopharmacol. 2013 Dec 12;150(3):1016-23. (PMID: 24157378)
Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):201-12. (PMID: 11173465)
Carbohydr Polym. 2018 Apr 15;186:100-109. (PMID: 29455967)
Comp Biochem Physiol B. 1985;82(1):117-22. (PMID: 2932279)
J Ethnopharmacol. 2018 Mar 1;213:395-402. (PMID: 29166575)
Laryngoscope. 2018 May;128(5):1157-1162. (PMID: 29076531)
J Pharm Pharmacol. 1979 Oct;31(10):681-5. (PMID: 91681)
Life Sci. 1978 Sep 11;23(10):1001-9. (PMID: 713678)
Biomed Pharmacother. 2019 Feb;110:631-640. (PMID: 30540974)
Braz Oral Res. 2019;33:e023. (PMID: 30970088)
Dig Dis Sci. 2010 Apr;55(4):911-9. (PMID: 19437118)
Regul Pept. 2009 Jun 5;155(1-3):11-7. (PMID: 19345246)
Molecules. 2010 Nov 24;15(12):8534-42. (PMID: 21107308)
Phytochemistry. 1998 Apr;47(7):1207-14. (PMID: 9611824)
Drug Dev Res. 2015 May;76(3):143-51. (PMID: 25959135)
Acta Cir Bras. 2015 May;30(5):353-8. (PMID: 26016935)
Nat Prod Res. 2014;28(10):753-6. (PMID: 24438027)
J Ethnopharmacol. 2012 Mar 27;140(2):203-12. (PMID: 22265748)
J Ethnopharmacol. 2018 Oct 5;224:27-35. (PMID: 29803569)
Br J Pharmacol. 2003 Apr;138(7):1259-70. (PMID: 12711626)
Toxins (Basel). 2013 Nov 07;5(11):2009-41. (PMID: 24212181)
Isr J Med Sci. 1984 Aug;20(8):681-4. (PMID: 6088428)
J Ethnopharmacol. 2007 Aug 15;113(1):156-70. (PMID: 17616289)
Nat Prod Res. 2019 Jun 14;:1-6. (PMID: 31198054)
J Pharmacol Exp Ther. 1994 Jan;268(1):291-5. (PMID: 8301570)
Carbohydr Polym. 2019 Dec 15;226:115205. (PMID: 31582062)
Nat Prod Res. 2013;27(16):1492-6. (PMID: 22974409)
Carbohydr Polym. 2012 Sep 1;90(1):270-4. (PMID: 24751040)
Nature. 1992 Feb 6;355(6360):561-4. (PMID: 1741035)
J Ethnopharmacol. 2013 Jun 21;148(1):218-22. (PMID: 23603196)
BMB Rep. 2017 Mar;50(3):111-116. (PMID: 27998396)
Naunyn Schmiedebergs Arch Pharmacol. 1999 Aug;360(2):221-3. (PMID: 10494894)
معلومات مُعتمدة: Edital FAPEPI/SESAPI/MS/CNPq/PPSUS/N◦ 002/2016 Research Foundation for the State of Piauí - FAPEPI; EDITAL FAPEPI / MCTIC/ CNPq Nº 008/2018 FAPEPI-CNPQ (PROGRAMA DE APOIO A NÚCLEOS EMERGENTES DE PESQUISA - PRONEM)
فهرسة مساهمة: Keywords: Escherichia coli; Fabaceae; cholera; diarrhea; polysaccharide
تواريخ الأحداث: Date Created: 20200123 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7168896
DOI: 10.3390/ph13010017
PMID: 31963683
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph13010017