دورية أكاديمية
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Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis.

التفاصيل البيبلوغرافية
العنوان: Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis.
المؤلفون: Cai L; Department of Pathology, School of Basic Medicine, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China., Mu YR; School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China., Liu MM; School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China., Tang WJ; School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China., Li R; School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China. Electronic address: aydlirong@163.com.
المصدر: International immunopharmacology [Int Immunopharmacol] 2020 Mar; Vol. 80, pp. 106182. Date of Electronic Publication: 2020 Jan 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2001-
مواضيع طبية MeSH: Antidepressive Agents/*pharmacology , Depression/*drug therapy , Iridoids/*pharmacology , Prefrontal Cortex/*drug effects , Stress, Psychological/*complications, Animals ; Antidepressive Agents/therapeutic use ; Chronic Disease/psychology ; Depression/etiology ; Depression/immunology ; Depression/psychology ; Disease Models, Animal ; Humans ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/immunology ; Inflammasomes/drug effects ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Iridoids/therapeutic use ; Male ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/immunology ; Prefrontal Cortex/immunology ; Prefrontal Cortex/pathology ; Rats ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Stress, Psychological/immunology ; Stress, Psychological/psychology
مستخلص: We previously reported that penta-acetyl geniposide ((Ac) 5 GP, an acetylated derivative of geniposide) exhibited better pharmacological functions than geniposide, a major active component of Gardenia jasminoides Ellis. This study demonstrated the antidepressant-like effects of (Ac) 5 GP and its involved mechanisms using a rat depression model caused by chronic unpredictable mild stress (CUMS). Behavioral tests including sucrose preference, open field and forced swimming were applied to evaluate depression symptoms. IL-1β, IL-6 and TNF-α mRNA and protein levels in prefrontal cortex (PFC) were respectively measured by quantitative PCR and ELISA. The protein levels of IκBα, p-IκBα, NF-κB p65, NLRP3, pro- and mature-IL-1β in PFC were determined by western blot. The activity of hypothalamic-pituitaryadrenal (HPA) axis was also measured. (Ac) 5 GP treatment alleviated the CUMS-induced depressive-like behaviors in rats, as indicated by increased sucrose intake, increased total crossing and rearing numbers, improved central activity and reduced immobility time. (Ac) 5 GP reversed the CUMS-induced elevations of IL-1β, IL-6 and TNF-α mRNA and protein levels in PFC. (Ac) 5 GP reduced degradation and phosphorylation of IκBα and protein level of nuclear NF-κB p65 in PFC. (Ac) 5 GP also decreased the mRNA and protein levels of NLRP3 and reduced the ratio of mature-IL-1β protein over total IL-1β protein (pro-IL-1β + mature-IL-1β) in PFC. Moreover, (Ac) 5 GP reduced serum levels of adrenocorticotropic hormone/corticosterone and mRNA level of hypothalamic corticotrophin-releasing hormone. In conclusion, (Ac) 5 GP treatment improved the depressive-like behaviors in CUMS rats perhaps by suppressing neuroinflammation in PFC and inhibiting activations of NF-κB and NLRP3 and also attenuating HPA axis hyperactivity.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Antidepressant; Chronic unpredictable mild stress; HPA axis; NF-κB pathway; Neuroinflammation; Penta-acetyl geniposide
المشرفين على المادة: 0 (Antidepressive Agents)
0 (Inflammasomes)
0 (Iridoids)
0 (NF-kappa B)
0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Nlrp3 protein, rat)
145295QLXY (geniposide)
تواريخ الأحداث: Date Created: 20200126 Date Completed: 20201124 Latest Revision: 20201124
رمز التحديث: 20231215
DOI: 10.1016/j.intimp.2019.106182
PMID: 31981962
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-1705
DOI:10.1016/j.intimp.2019.106182