دورية أكاديمية
Effect of the antiviral compound MDL 20,610 on some aspects of murine immune function.
| العنوان: | Effect of the antiviral compound MDL 20,610 on some aspects of murine immune function. |
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| المؤلفون: | Kenny MT; Merrell Dow Research Institute, Indianapolis, IN 46268-0470., Dulworth JK, Torney HL, Cheng WD, Roberds SL, Graham MC |
| المصدر: | International journal of immunopharmacology [Int J Immunopharmacol] 1988; Vol. 10 (6), pp. 639-49. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 7904799 Publication Model: Print Cited Medium: Print ISSN: 0192-0561 (Print) Linking ISSN: 01920561 NLM ISO Abbreviation: Int J Immunopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford ; Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Immune System/*drug effects , Pyridines/*pharmacology, Adjuvants, Immunologic ; Animals ; Antiviral Agents/pharmacology ; Female ; Hypersensitivity, Delayed ; Immunoglobulin M/biosynthesis ; In Vitro Techniques ; Killer Cells, Natural/drug effects ; Macrophages/drug effects ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred Strains ; Neutrophils/drug effects ; Neutrophils/immunology |
| مستخلص: | At physiologically relevant concentrations an antiviral compound should not perturb the host's ability to mount an immune response against the infecting virus or some other opportunistic pathogen. The purpose of this study was to evaluate the immunomodulatory activity of the antiviral compound MDL 20,610 using murine models. When tested in vitro at the limit of aqueous solubility (6 microM), MDL 20,610 has no significant effect on neutrophil function as assessed by cell migration against FMLP and LTB4 gradients, myeloperoxidase secretion or 0.-2 production. In addition, 6 microM MDL 20,610 has no significant effect on macrophage function as determined by 0.-2 production, Ia and Mac-1 antigen expression and expression of Fc gamma receptors. Finally, MDL 20,610 does not significantly affect in vivo (1-100 mg/kg/day) NK cell activity or DTH to oxazolone; but treatment of mice with 50 or 100 mg MDL 20,610/kg/day significantly (P less than 0.01) enhances SRBC IgM antibody synthesis. These data indicate that MDL 20,610 is relatively devoid of immunomodulatory activity. |
| المشرفين على المادة: | 0 (Adjuvants, Immunologic) 0 (Antiviral Agents) 0 (Immunoglobulin M) 0 (Pyridines) 102830-69-3 (MDL 20610) |
| تواريخ الأحداث: | Date Created: 19880101 Date Completed: 19890118 Latest Revision: 20190908 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0192-0561(88)90017-3 |
| PMID: | 3198304 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0192-0561 |
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| DOI: | 10.1016/0192-0561(88)90017-3 |