دورية أكاديمية
Human T lymphotropic virus type I antibody patterns: evidence of difference by age and risk group.
| العنوان: | Human T lymphotropic virus type I antibody patterns: evidence of difference by age and risk group. |
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| المؤلفون: | Agius G; Viral Epidemiology Section, National Cancer Institute, Bethesda, Maryland 20892., Biggar RJ, Alexander SS, Waters DJ, Drummond JE, Murphy EL, Weiss SH, Levine PH, Blattner WA |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 1988 Dec; Vol. 158 (6), pp. 1235-44. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Print ISSN: 0022-1899 (Print) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | HTLV-I Antibodies/*analysis , HTLV-I Infections/*epidemiology, Adolescent ; Adult ; Africa, Western ; Age Factors ; Aged ; Aged, 80 and over ; Blotting, Western ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; HTLV-I Infections/immunology ; Humans ; Jamaica ; Japan ; Leukemia/immunology ; Leukemia-Lymphoma, Adult T-Cell/immunology ; Lymphoma/immunology ; Middle Aged ; Panama ; Predictive Value of Tests ; Radioimmunoassay ; Risk Factors ; United States |
| مستخلص: | Detection of human T lymphotropic virus type I (HTLV-I) antibody was assessed on 368 sera from subjects with different clinical features and from different parts of the world. Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay for purified p24 antibodies (p24-RIA) used as screening tests agreed in 88.7% of the sera. The results from 247 selected sera were compared with western blot (WB). WB was reactive in sera five to 25 times more dilute than the last positive ELISA or p24-RIA, but different WB batches varied in sensitivity. ELISA was more sensitive than p24-RIA, and p24-RIA was more specific than ELISA. Indeterminate WB interpretations were common (25.5%). Most seropositive intravenous drug abusers had unusually strong p24 bands by WB. Among healthy individuals, positive WB reactivity increased with age, whereas indeterminate reactivity declined (P = .034). Thus, more-sensitive and -specific HTLV-I antibody tests are needed. |
| المشرفين على المادة: | 0 (HTLV-I Antibodies) |
| تواريخ الأحداث: | Date Created: 19881201 Date Completed: 19890117 Latest Revision: 20190510 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/infdis/158.6.1235 |
| PMID: | 3198937 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-1899 |
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| DOI: | 10.1093/infdis/158.6.1235 |