دورية أكاديمية
Nanodelivery of Natural Antioxidants: An Anti-aging Perspective.
| العنوان: | Nanodelivery of Natural Antioxidants: An Anti-aging Perspective. |
|---|---|
| المؤلفون: | Vaiserman A; Laboratory of Epigenetics, D.F. Chebotarev Institute of Gerontology, NAMS, Kyiv, Ukraine., Koliada A; Laboratory of Epigenetics, D.F. Chebotarev Institute of Gerontology, NAMS, Kyiv, Ukraine., Zayachkivska A; Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine., Lushchak O; Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine. |
| المصدر: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2020 Jan 10; Vol. 7, pp. 447. Date of Electronic Publication: 2020 Jan 10 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101632513 Publication Model: eCollection Cited Medium: Print ISSN: 2296-4185 (Print) Linking ISSN: 22964185 NLM ISO Abbreviation: Front Bioeng Biotechnol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress. (Copyright © 2020 Vaiserman, Koliada, Zayachkivska and Lushchak.) |
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| فهرسة مساهمة: | Keywords: age-associated disorders; anti-inflammatory properties; bioavailability; nano-antioxidants; nanodelivery; oxidative stress; phytochemicals |
| تواريخ الأحداث: | Date Created: 20200131 Latest Revision: 20240327 |
| رمز التحديث: | 20240327 |
| مُعرف محوري في PubMed: | PMC6965023 |
| DOI: | 10.3389/fbioe.2019.00447 |
| PMID: | 31998711 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-4185 |
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| DOI: | 10.3389/fbioe.2019.00447 |