دورية أكاديمية
أعرض في EDS

Spirometry in Central Asian Lowlanders and Highlanders, a Population Based Study.

التفاصيل البيبلوغرافية
العنوان: Spirometry in Central Asian Lowlanders and Highlanders, a Population Based Study.
المؤلفون: Ulrich S; Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland., Furian M; Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland., Estebesova B; Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan., Toktogulova N; Therapy 1 Department, Medical Faculty, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan., Beishekeeva G; Therapy 1 Department, Medical Faculty, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan., Ulrich S; Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland., Burney PGJ; Population Health and Occupational Disease, National Heart and Lung Institute & MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom., Sooronbaev TM; Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan., Bloch KE; Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland.
المصدر: Frontiers in medicine [Front Med (Lausanne)] 2020 Jan 10; Vol. 6, pp. 308. Date of Electronic Publication: 2020 Jan 10 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]-
مستخلص: Introduction: The purpose of the study was to establish spirometric reference values for a Central Asian population of highlanders and lowlanders. Methods: Spirometries from a population-based cross-sectional study performed in 2013 in rural areas of Kyrgyzstan were analyzed. Using multivariable linear regression, Global Lung Function Initiative (GLI) equations were fitted separately for men and women, and altitude of residence (700-800 m, 1,900-2,800 m) to data from healthy, never-smoking Kyrgyz adults. The general GLI equation was applied: Predicted value = e a 0 + a 1 ×  ln ( Height ) + a 2 ×  ln ( Age ) + b 1 ×  ln ( Age 100 ) + b 2 ×  ln ( Age 100 ) 2 + b 3 ×  ln ( Age 100 ) 3              + b 4 ×  ln ( Age 100 ) 4 + b 5 ×  ln ( Age 100 ) 5 Results: Of 2,784 screened Kyrgyz, 448 healthy, non-smoking highlanders (379 females) and 505 lowlanders (368 females), aged 18-91 years, were included. Predicted FVC in Kyrgyz fit best with GLI "North-East Asians," predicted FEV 1 fit best with GLI "Other/Mixed." Predicted FEV 1 /FVC was lower than that of all GLI categories. Age- and sex-adjusted mean FVC and FEV 1 were higher in highlanders (+0.138l, +0.132l) than in lowlanders ( P < 0.001, all comparisons), but FEV 1 /FVC was similar. Conclusion: We established prediction equations for an adult Central Asian population indicating that FVC is similar to GLI "North-East Asian" and FEV 1 /FVC is lower than in all other GLI population categories, consistent with a relatively smaller airway caliber. Central Asian highlanders have significantly greater dynamic lung volumes compared to lowlanders, which may be due to environmental and various other effects.
(Copyright © 2020 Ulrich, Furian, Estebesova, Toktogulova, Beishekeeva, Ulrich, Burney, Sooronbaev and Bloch.)
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فهرسة مساهمة: Keywords: Central Asian; altitude; highlanders; lung function; spirometry
تواريخ الأحداث: Date Created: 20200131 Latest Revision: 20200929
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6966711
DOI: 10.3389/fmed.2019.00308
PMID: 31998729
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-858X
DOI:10.3389/fmed.2019.00308