دورية أكاديمية
أعرض في EDS

Serum bicarbonate is a marker of peri-operative mortality but is not associated with long term survival in colorectal cancer.

التفاصيل البيبلوغرافية
العنوان: Serum bicarbonate is a marker of peri-operative mortality but is not associated with long term survival in colorectal cancer.
المؤلفون: Chan JCY; Bill Walsh Translational Research Laboratories, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia., Diakos CI; Bill Walsh Translational Research Laboratories, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Northern Sydney Cancer Center, Royal North Shore Hospital, St Leonards, New South Wales, Australia., Engel A; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Department of Colorectal Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia., Chan DLH; Bill Walsh Translational Research Laboratories, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Northern Sydney Cancer Center, Royal North Shore Hospital, St Leonards, New South Wales, Australia., Pavlakis N; Bill Walsh Translational Research Laboratories, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Northern Sydney Cancer Center, Royal North Shore Hospital, St Leonards, New South Wales, Australia., Gill A; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia., Clarke SJ; Bill Walsh Translational Research Laboratories, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia.; Northern Sydney Cancer Center, Royal North Shore Hospital, St Leonards, New South Wales, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia.
المصدر: PloS one [PLoS One] 2020 Jan 30; Vol. 15 (1), pp. e0228466. Date of Electronic Publication: 2020 Jan 30 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Bicarbonates/*blood , Biomarkers, Tumor/*blood , Colorectal Neoplasms/*surgery , Perioperative Period/*mortality, Aged ; Aged, 80 and over ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/pathology ; Female ; Humans ; Kaplan-Meier Estimate ; Lymphocyte Count ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Neutrophils/metabolism ; Prognosis ; Tumor Microenvironment
مستخلص: Aims: Inflammation is a hallmark of cancer whose activity is modulated within the tumor microenvironment by low tumoral pH. Recent evidence in the literature has suggested a link between low serum bicarbonate, low tumoral pH and cancer related inflammation. There is however little clinical evidence in human patients regarding the prognostic role of serum bicarbonate. Therefore, the primary aim of this study was to investigate the short and long-term prognostic utility of serum bicarbonate in colorectal cancer (CRC) patients undergoing resection of their primary tumor. The study also aimed to investigate the association of serum bicarbonate with known markers of systemic inflammation.
Methods: A total of 3281 consecutive patients who underwent surgical resection of their primary CRC from January 1998 to December 2012. Of these, 2223 stage I-IV patients had available data for analysis. The association of serum bicarbonate with overall survival was assessed using univariate and multivariate cox regression analyses. The association of bicarbonate with other clinicopathological variables was assessed by chi squared and Fisher's exact tests.
Results: Serum bicarbonate was associated with peri-operative mortality in multivariate analysis (p<0.001). Age (p = 0.004), grade (p = 0.043), creatinine (p = 0.036) and sodium (p = 0.036) were also markers associated with peri-operative mortality. For long term survival at 5 years, bicarbonate was significantly associated with overall survival in univariate analysis (p<0.001) but was not significant in multivariate analysis (p = 0.075). In exploratory analysis, serum bicarbonate was found to be significantly associated with the lymphocyte-to-monocyte ratio (p<0.001) and neutrophil-to-lymphocyte ratio (p<0.001).
Conclusions: In peri-operative colorectal cancer patients, serum bicarbonate was associated with 30-day survival but not 5-year survival.
Competing Interests: The authors have declared that no competing interests exist.
التعليقات: Erratum in: PLoS One. 2021 Aug 5;16(8):e0244898. (PMID: 34351923)
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المشرفين على المادة: 0 (Bicarbonates)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20200131 Date Completed: 20200420 Latest Revision: 20210805
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6992208
DOI: 10.1371/journal.pone.0228466
PMID: 31999779
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0228466