دورية أكاديمية
أعرض في EDS

Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men.

التفاصيل البيبلوغرافية
العنوان: Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men.
المؤلفون: Verboeket SO; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.; Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands., Wit FW; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.; Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.; HIV Monitoring Foundation, Amsterdam, the Netherlands., Verheij E; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.; Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands., van Zoest RA; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.; Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands., Kootstra NA; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam, the Netherlands., van der Valk M; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Prins JM; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Schim van der Loeff MF; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.; Public Health Service of Amsterdam, Department of Infectious Diseases, Amsterdam, the Netherlands., Reiss P; Amsterdam UMC, University of Amsterdam, Departments of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.; Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.; HIV Monitoring Foundation, Amsterdam, the Netherlands.
مؤلفون مشاركون: AGEhIV Study Group
المصدر: The Journal of infectious diseases [J Infect Dis] 2021 Oct 13; Vol. 224 (7), pp. 1187-1197.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: CD4-CD8 Ratio* , HIV Seronegativity* , HIV Seropositivity* , Heterosexuality* , Homosexuality, Male*, CD8-Positive T-Lymphocytes/*immunology , HIV Infections/*blood, Aged ; Aged, 80 and over ; CD4-Positive T-Lymphocytes ; Cytomegalovirus Infections/epidemiology ; Female ; HIV ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Seroepidemiologic Studies ; Sexual Behavior ; Sexually Transmitted Diseases
مستخلص: Background: We previously reported T-cell senescence to be similar in people with human immunodeficiency virus (PWH) with suppressed viremia (predominantly men who have sex with men [MSM]) and human immunodeficiency virus (HIV)-negative otherwise comparable controls but greater than in healthy blood donors. This led us to compare CD4+ and CD8+ T-cell counts and CD4+/CD8+ ratios between HIV-negative MSM and men who only have sex with women (MSW) and relate observed differences in behavioral factors and infectious exposures, including cytomegalovirus (CMV) infection.
Methods: In 368 HIV-negative MSM and 72 HIV-negative MSW, T lymphocyte phenotyping was performed 3 times biennially. Baseline CMV serology and sexually transmitted infection (STI) incidence and/or STI seroprevalence, sexual, and substance-use behavior data were collected during study visits.
Results: Men who have sex with men, compared with MSW, had higher CD8+ counts (551 vs 437 cells/mm3, P < .001), similar CD4+ counts (864 vs 880 cells/mm3, P = .5), and lower CD4+/CD8+ ratios (1.84 vs 2.47, P < .001). Differences were most pronounced for MSM with >10 recent sex partners and partly explained by higher CMV seroprevalence in MSM.
Conclusions: These findings suggest that factors other than HIV may, in both PWH and certain HIV-negative MSM, contribute to a low CD4+/CD8+ ratio. Whether this, like in PWH, contributes to comorbidity risk in HIV-negative MSM requires further study.
(© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.)
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فهرسة مساهمة: Keywords: CD4-CD8 ratio; HIV; cytomegalovirus; men who have sex with men; sexual and gender minorities
تواريخ الأحداث: Date Created: 20200201 Date Completed: 20220224 Latest Revision: 20220224
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8514179
DOI: 10.1093/infdis/jiaa048
PMID: 32003801
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiaa048