دورية أكاديمية
أعرض في EDS

Photodynamic therapy mediated by aluminium-phthalocyanine nanoemulsion eliminates primary tumors and pulmonary metastases in a murine 4T1 breast adenocarcinoma model.

التفاصيل البيبلوغرافية
العنوان: Photodynamic therapy mediated by aluminium-phthalocyanine nanoemulsion eliminates primary tumors and pulmonary metastases in a murine 4T1 breast adenocarcinoma model.
المؤلفون: Rodrigues MC; Laboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF 72220-900, Brazil; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Vieira LG; Laboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF 72220-900, Brazil; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Horst FH; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., de Araújo EC; Laboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF 72220-900, Brazil; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Ganassin R; Laboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF 72220-900, Brazil; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Merker C; Institute of Medical Physics & Biophysics, Leipzig University, Leipzig 04107, Germany., Meyer T; Institute of Medical Physics & Biophysics, Leipzig University, Leipzig 04107, Germany., Böttner J; Institute of Medical Physics & Biophysics, Leipzig University, Leipzig 04107, Germany., Venus T; Institute of Medical Physics & Biophysics, Leipzig University, Leipzig 04107, Germany., Longo JPF; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Chaves SB; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Garcia MP; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Estrela-Lopis I; Institute of Medical Physics & Biophysics, Leipzig University, Leipzig 04107, Germany., Azevedo RB; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil., Muehlmann LA; Laboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF 72220-900, Brazil; Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil. Electronic address: luisalex@unb.br.
المصدر: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2020 Mar; Vol. 204, pp. 111808. Date of Electronic Publication: 2020 Jan 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Elsevier Sequoia, 1987-
مواضيع طبية MeSH: Adenocarcinoma/*drug therapy , Aluminum/*chemistry , Breast Neoplasms/*drug therapy , Indoles/*chemistry , Lung Neoplasms/*drug therapy , Nanostructures/*chemistry , Photosensitizing Agents/*therapeutic use, Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Animals ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Female ; Isoindoles ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/secondary ; Mice ; Mice, Inbred BALB C ; Nanostructures/therapeutic use ; Nanostructures/toxicity ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/toxicity ; Reactive Oxygen Species/metabolism ; Transplantation, Homologous ; X-Ray Microtomography
مستخلص: Photodynamic therapy (PDT) is effective in the treatment of different types of cancer, such as basal cell carcinoma and other superficial cancers. However, improvements in photosensitizer delivery are still needed, and the use of PDT against more deeply located tumors has been the subject of many studies. Thus, the goal of this study was to evaluate the efficacy of a nanoemulsion containing aluminium-phthalocyanine (AlPc-NE) as a mediator of photodynamic therapy (PDT-AlPc-NE) against grafted 4T1 breast adenocarcinoma tumors in mice (BALB/c). Short after the appearance of the tumor, the animals were divided into groups (n = 5) as follows: untreated; only AlPc-NE and treated with PDT-AlPc-NE. The tumor volume was measured with a digital calliper at specific times. The presence of metastasis in the lungs was evaluated by microtomography and histopathological analyses. The results show that the application of PDT-AlPc-NE eradicated the transplanted tumors in all the treated animals, while the animals from control groups presented a robust increase in the tumor volume. Still more significantly, microtomography showed the animals submitted the PDT-AlPc-NE to be free of detectable metastasis in the lungs. The histological analysis of the lungs further confirmed the results verified by the microtomography. Therefore, this study suggests that PDT-AlPc-NE is effective in the elimination of experimentally grafted breast tumors in mice and also in preventing the formation of metastasis in the lungs.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Abscopal; Cancer; Nanotechnology; Photosensitizer
المشرفين على المادة: 0 (Indoles)
0 (Isoindoles)
0 (Photosensitizing Agents)
0 (Reactive Oxygen Species)
CPD4NFA903 (Aluminum)
V5PUF4VLGY (phthalocyanine)
تواريخ الأحداث: Date Created: 20200202 Date Completed: 20200311 Latest Revision: 20211204
رمز التحديث: 20221213
DOI: 10.1016/j.jphotobiol.2020.111808
PMID: 32006892
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2682
DOI:10.1016/j.jphotobiol.2020.111808