دورية أكاديمية
أعرض في EDS

Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.

التفاصيل البيبلوغرافية
العنوان: Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.
المؤلفون: Lisboa JVC; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Ribeiro MR; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Luna RCP; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Lima RPA; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Nascimento RAFD; Postgraduate Program in Molecular and Human Biology, Center of Exact and Natural Sciences, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Monteiro MGCA; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Lima KQF; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Fechine CPNDS; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Oliveira NFP; Departament of Molecular Biology, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Persuhn DC; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Veras RC; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Gonçalves MDCR; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Ferreira FELL; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Lima RT; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Silva ASD; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Diniz ADS; Postgraduate Program in Nutrition Sciences, Federal University of Pernambuco, Recife 50670901, Brazil., Almeida ATC; Department of Economics, Postgraduate Program in App1lied Economics and Economics of the Public Sector, Center for Applied Social Sciences, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Moraes RM; Postgraduate Program in Health Decision Models, Federal University of Paraíba, João Pessoa 58059-900, Brazil., Junior EV; Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro 20550-900, Brazil., Costa MJC; Postgraduate Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraíba, João Pessoa 58059-900, Brazil.
المصدر: Nutrients [Nutrients] 2020 Jan 30; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 30.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Vegetables*, Folic Acid/*administration & dosage , Methylenetetrahydrofolate Reductase (NADPH2)/*genetics , Obesity/*genetics , Overweight/*genetics, Adult ; Diet/methods ; Diet Surveys ; Double-Blind Method ; Female ; Folic Acid/blood ; Genotype ; Homocysteine/blood ; Humans ; Interleukin-1beta/blood ; Interleukin-6/blood ; Middle Aged ; Nutrigenomics ; Obesity/blood ; Obesity/diet therapy ; Overweight/blood ; Overweight/diet therapy ; Polymorphism, Genetic ; Tumor Necrosis Factor-alpha/blood ; Vitamin B 12/blood
مستخلص: Methylenetetrahydrofolate reductase ( MTHFR ) C677T polymorphism associated with body fat accumulation could possibly trigger an inflammatory process by elevating homocysteine levels and increasing cytokine production, causing several diseases. This study aimed to evaluate the effects of food intervention, and not folate supplements, on the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in overweight and obese women with the MTHFR C677T polymorphism. A randomized, double-blind eight-week clinical trial of 48 overweight and obese women was conducted. Participants were randomly assigned into two groups. They received 300 g of vegetables daily for eight weeks containing different doses of folate: 95 µg/day for Group 1 and 191 µg/day for Group 2. MTHFR C677T polymorphism genotyping was assessed by digestion with HinfI enzyme and on 12% polyacrylamide gels. Anthropometric measurements, 24-h dietary recall, and biochemical analysis (blood folic acid, vitamin B12, homocysteine (Hcy), TNF-α, IL-1β, and IL-6) were determined at the beginning and end of the study. Group 2 had a significant increase in folate intake ( p < 0.001) and plasma folic acid ( p < 0.05) for individuals with the cytosine-cytosine (CC), cytosine-thymine (CT), and thymine-thymine (TT) genotypes. However, only individuals with the TT genotype presented reduced levels of Hcy, TNF-α, IL-6, and IL-1β ( p < 0.001). Group 1 showed significant differences in folate consumption ( p < 0.001) and folic acid levels ( p < 0.05) for individuals with the CT and TT genotypes. Food intervention with folate from vegetables increased folic acid levels and reduced interleukins, TNF-α, and Hcy levels, mainly for individuals with the TT genotype.
Competing Interests: The authors declare that they have no competing interests.
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معلومات مُعتمدة: public notice 001/2013 under the number EFP_00008187 Foundation for Support and Research Support/PPSUS/PB/Ministry of Health/National Research Council/CNPq/João Pessoa Prefecture
فهرسة مساهمة: Keywords: dietary intervention; folate; genetic variants; interleukins; obesity; overweight; polymorphism; tumor necrosis factor-alpha
المشرفين على المادة: 0 (IL6 protein, human)
0 (Interleukin-1beta)
0 (Interleukin-6)
0 (Tumor Necrosis Factor-alpha)
0LVT1QZ0BA (Homocysteine)
935E97BOY8 (Folic Acid)
EC 1.5.1.20 (MTHFR protein, human)
EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
P6YC3EG204 (Vitamin B 12)
تواريخ الأحداث: Date Created: 20200206 Date Completed: 20201019 Latest Revision: 20240727
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC7071147
DOI: 10.3390/nu12020361
PMID: 32019154
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu12020361