دورية أكاديمية
أعرض في EDS

Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice.

التفاصيل البيبلوغرافية
العنوان: Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice.
المؤلفون: Malaviarachchi PA; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Mercado MAB; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., McSorley SJ; Center for Comparative Medicine, Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, USA., Li LX; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
المصدر: European journal of immunology [Eur J Immunol] 2020 May; Vol. 50 (5), pp. 676-684. Date of Electronic Publication: 2020 Mar 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Antibodies, Bacterial/*biosynthesis , B-Lymphocytes/*immunology , Bacteremia/*immunology , Bone Marrow Cells/*immunology , CD4-Positive T-Lymphocytes/*immunology , Chlamydia Infections/*immunology , Chlamydia trachomatis/*immunology, Animals ; Antigen Presentation ; B-Lymphocytes/microbiology ; Bacteremia/microbiology ; Bacteremia/pathology ; Bone Marrow Cells/microbiology ; CD4-Positive T-Lymphocytes/microbiology ; Chlamydia Infections/microbiology ; Chlamydia Infections/pathology ; Chlamydia trachomatis/growth & development ; Chlamydia trachomatis/pathogenicity ; Disease Models, Animal ; Female ; Immunity, Humoral ; Immunoglobulin Isotypes ; Mice ; Transplantation Chimera ; Vagina/immunology ; Vagina/microbiology ; Whole-Body Irradiation
مستخلص: The obligate intracellular bacterium Chlamydia trachomatis causes the most prevalent bacterial sexually transmitted infection worldwide. CD4 T cells play a central role in the protective immunity against Chlamydia female reproductive tract (FRT) infection, while B cells are thought to be dispensable for resolution of primary Chlamydia infection in mouse models. We recently reported an unexpected requirement of B cells in local Chlamydia-specific CD4 T-cell priming and bacterial containment within the FRT. Here, we sought to tackle the precise effector function of B cells during Chlamydia primary infection. Using mixed bone marrow chimeras that lack B-cell-dependent Ag presentation (MHCII B - / - ) or devoid of circulating antibodies (AID -/- × μS -/- ), we show that Chlamydia-specific CD4 T-cell expansion does not rely on Ag presentation by B cells. Importantly, we demonstrate that antibody, but not B-cell-dependent Ag presentation, is required for preventing systemic bacterial dissemination following Chlamydia FRT infection.
(© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
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معلومات مُعتمدة: P20 GM109005 United States GM NIGMS NIH HHS; R01 AI139047 United States AI NIAID NIH HHS; R01 AI139124 United States AI NIAID NIH HHS; R21 AI117303 United States AI NIAID NIH HHS; P30 GM145393 United States GM NIGMS NIH HHS; P20 GM103625 United States GM NIGMS NIH HHS; R01 AI103422 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Antibody; Antigen presentation; B cells; Chlamydia; Infection
المشرفين على المادة: 0 (Antibodies, Bacterial)
0 (Immunoglobulin Isotypes)
تواريخ الأحداث: Date Created: 20200207 Date Completed: 20201028 Latest Revision: 20230217
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7199221
DOI: 10.1002/eji.201948391
PMID: 32026472
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4141
DOI:10.1002/eji.201948391