دورية أكاديمية
Mechanism of indoleamine 2, 3-dioxygenase inhibiting cardiac allograft rejection in mice.
| العنوان: | Mechanism of indoleamine 2, 3-dioxygenase inhibiting cardiac allograft rejection in mice. |
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| المؤلفون: | Li C; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Sun Z; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Yuan F; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Zhao Z; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Zhang J; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Zhang B; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Li H; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Liu T; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China., Dai X; Department of General Surgery, Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Heping District, China. |
| المصدر: | Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Mar; Vol. 24 (6), pp. 3438-3448. Date of Electronic Publication: 2020 Feb 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Bucharest : "Carol Davila" University Press, 2000- |
| مواضيع طبية MeSH: | Graft Rejection/*immunology , Heart Transplantation/*adverse effects , Immune Tolerance/*immunology , Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism , Transplantation, Homologous/*adverse effects , Tryptophan/*metabolism, Animals ; Cell Proliferation ; Cells, Cultured ; Dendritic Cells/immunology ; Graft Rejection/prevention & control ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; T-Lymphocytes/immunology |
| مستخلص: | Indoleamine 2, 3-dioxygenase (IDO)-mediated regulation of tryptophan metabolism plays an important role in immune tolerance in transplantation, but it has not been elucidated which mechanism specifically induces the occurrence of immune tolerance. Our study revealed that IDO exerts immunosuppressive effects through two pathways in mouse heart transplantation, 'tryptophan depletion' and 'tryptophan metabolite accumulation'. The synergism between IDO + DC and TC (tryptophan catabolic products) has stronger inhibitory effects on T lymphocyte proliferation and mouse heart transplant rejection than the two intervention factors alone, and significantly prolong the survival time of donor-derived transplanted skin. This work demonstrates that the combination of IDO + DC and TC can induce immune tolerance to a greater extent, and reduce the rejection of transplanted organs. (© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: allograft rejection; cardiac transplantation; immune tolerance; indoleamine 2,3-dioxygenase |
| المشرفين على المادة: | 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase) 8DUH1N11BX (Tryptophan) |
| تواريخ الأحداث: | Date Created: 20200207 Date Completed: 20210909 Latest Revision: 20210909 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7131949 |
| DOI: | 10.1111/jcmm.15024 |
| PMID: | 32027774 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1582-4934 |
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| DOI: | 10.1111/jcmm.15024 |