دورية أكاديمية
The Neuroprotective Role of Reactive Astrocytes after Central Nervous System Injury.
| العنوان: | The Neuroprotective Role of Reactive Astrocytes after Central Nervous System Injury. |
|---|---|
| المؤلفون: | Boghdadi AG; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia., Teo L; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia., Bourne JA; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia. |
| المصدر: | Journal of neurotrauma [J Neurotrauma] 2020 Mar 01; Vol. 37 (5), pp. 681-691. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1988- |
| مواضيع طبية MeSH: | Astrocytes/*physiology , Brain Injuries/*physiopathology , Neuroprotection/*physiology , Spinal Cord Injuries/*physiopathology, Gliosis/physiopathology ; Humans |
| مستخلص: | Reactive astrocytes have traditionally been viewed as a significant contributor to secondary neuronal damage and repair inhibition after central nervous system (CNS) injury attributed, in large part, to their roles in glial scarring. However, more recent transcriptional evidence has uncovered the vast diversity in reactive astrocyte identity and functions that comprises both neuroprotective and -toxic characteristics. Additionally, the capacity of reactive astrocytes to shift between these activation states demonstrates a high level of environment-dependent plasticity that drives the interplay between neuroprotection and -toxicity after CNS injury. These recent findings have spawned a new field of research that seeks to identify and categorize the function of these discrete subpopulations in the context of neurotrauma, as well as identify their regulators. Therefore, this review will discuss the major and most recent advances in this field of research, with a primary emphasis on neuroprotection. This review will also discuss the major pitfalls present in the field, with a particular focus on model species and their impact on the development of novel therapies. |
| فهرسة مساهمة: | Keywords: astrocyte; glia; neuroprotection; neurotoxicity; neurotrauma |
| تواريخ الأحداث: | Date Created: 20200208 Date Completed: 20210819 Latest Revision: 20210819 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1089/neu.2019.6938 |
| PMID: | 32031052 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1557-9042 |
|---|---|
| DOI: | 10.1089/neu.2019.6938 |