دورية أكاديمية
أعرض في EDS

Antidiarrheal activity of farnesol in rodents: Pharmacological actions and molecular docking.

التفاصيل البيبلوغرافية
العنوان: Antidiarrheal activity of farnesol in rodents: Pharmacological actions and molecular docking.
المؤلفون: da Costa DS; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Negreiros PDS; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., da Silva VG; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Nunes DB; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., Acha BT; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., Quintans-Junior LJ; Laboratory of Pharmacology of Inflammation and Gastrointestinal Diseases, Federal University of Piauí, Parnaíba, PI, Brazil., Antunes de Souza Araújo A; Laboratory of Pharmacology of Inflammation and Gastrointestinal Diseases, Federal University of Piauí, Parnaíba, PI, Brazil., Araújo TSL; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Sousa FBM; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Medeiros JVR; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Lima FDCA; Chemistry Department of Piauí State University, Teresina, PI, Brazil., da Silva FI; Chemistry Department of Piauí State University, Teresina, PI, Brazil., Magalhães Costa RK; Chemistry Department of Piauí State University, Teresina, PI, Brazil., Santos RFD; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., Oliveira RCM; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil. Electronic address: menesesoliveira@gmail.com.
المصدر: European journal of pharmacology [Eur J Pharmacol] 2020 May 05; Vol. 874, pp. 172986. Date of Electronic Publication: 2020 Feb 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
مواضيع طبية MeSH: Antidiarrheals/*pharmacology , Antidiarrheals/*therapeutic use , Diarrhea/*drug therapy , Diarrhea/*metabolism , Farnesol/*pharmacology , Farnesol/*therapeutic use, Animals ; Castor Oil ; Chlorides/metabolism ; Cholera Toxin ; Diarrhea/chemically induced ; Dinoprostone ; Female ; Gastrointestinal Motility/drug effects ; Intestinal Absorption/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Secretions/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Receptors, Cell Surface/metabolism
مستخلص: Diarrhea is a condition in which the individual has about three or more daily bowel movements, followed by changes in stool consistency. It is currently considered as one of the worst public health problems due to the number of cases and deaths involved and difficulty of treatment. Thus, the use of natural products is an alternative for new treatments. Among these possibilities is Farnesol (C 15 H 26 O), a sesquiterpene found in different herbal species that has known biological activities. The objective of this study was to evaluate the antidiarrheal activity of Farnesol (FOH). Initially, FOH activity was evaluated in models of diarrhea and enteropooling induced by castor oil and PGE 2 . To evaluate motility, the opioid and cholinergic pathways were studied. In addition, the effect of FOH was investigated in the secretion model in intestinal loops treated with cholera toxin. FOH was evaluated for the ability to absorb fluids in intestinal loops and interact with GM1 receptors using the ELISA method and molecular docking. The dose of 50 mg/kg of FOH showed the best results in all antidiarrheal activity tests with castor oil and PGE 2 , being considered as the standard dose, reducing motility by anticholinergic mechanisms. There was a reduction in fluid secretion when FOH interacted directly with GM1 receptors; cholera toxin and molecular docking showed strong interaction between farnesol and these targets. In view of the results presented, the antidiarrheal activity occurs through anticholinergic, anti-inflammatory and anti-secretory action, making farnesol a potential candidate for the development of a new drug to treat diarrheal diseases.
Competing Interests: Declaration of competing interest None.
(Copyright © 2020. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Castor oil; Cholera; Farnesol; Gastrointestinal transit; Sesquiterpene
المشرفين على المادة: 0 (Antidiarrheals)
0 (Chlorides)
0 (Narcotic Antagonists)
0 (Receptors, Cell Surface)
0 (ganglioside receptor)
36B82AMQ7N (Naloxone)
4602-84-0 (Farnesol)
8001-79-4 (Castor Oil)
9012-63-9 (Cholera Toxin)
K7Q1JQR04M (Dinoprostone)
تواريخ الأحداث: Date Created: 20200208 Date Completed: 20201201 Latest Revision: 20201201
رمز التحديث: 20240628
DOI: 10.1016/j.ejphar.2020.172986
PMID: 32032601
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0712
DOI:10.1016/j.ejphar.2020.172986