دورية أكاديمية
Antidiarrheal activity of farnesol in rodents: Pharmacological actions and molecular docking.
العنوان: | Antidiarrheal activity of farnesol in rodents: Pharmacological actions and molecular docking. |
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المؤلفون: | da Costa DS; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Negreiros PDS; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., da Silva VG; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Nunes DB; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., Acha BT; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., Quintans-Junior LJ; Laboratory of Pharmacology of Inflammation and Gastrointestinal Diseases, Federal University of Piauí, Parnaíba, PI, Brazil., Antunes de Souza Araújo A; Laboratory of Pharmacology of Inflammation and Gastrointestinal Diseases, Federal University of Piauí, Parnaíba, PI, Brazil., Araújo TSL; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Sousa FBM; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Medeiros JVR; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil., Lima FDCA; Chemistry Department of Piauí State University, Teresina, PI, Brazil., da Silva FI; Chemistry Department of Piauí State University, Teresina, PI, Brazil., Magalhães Costa RK; Chemistry Department of Piauí State University, Teresina, PI, Brazil., Santos RFD; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil., Oliveira RCM; Post-Graduation Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, PI, Brazil; Medicinal Plants Research Center (NPPM), Federal University of Piauí, Teresina, PI, Brazil. Electronic address: menesesoliveira@gmail.com. |
المصدر: | European journal of pharmacology [Eur J Pharmacol] 2020 May 05; Vol. 874, pp. 172986. Date of Electronic Publication: 2020 Feb 04. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
مواضيع طبية MeSH: | Antidiarrheals/*pharmacology , Antidiarrheals/*therapeutic use , Diarrhea/*drug therapy , Diarrhea/*metabolism , Farnesol/*pharmacology , Farnesol/*therapeutic use, Animals ; Castor Oil ; Chlorides/metabolism ; Cholera Toxin ; Diarrhea/chemically induced ; Dinoprostone ; Female ; Gastrointestinal Motility/drug effects ; Intestinal Absorption/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Secretions/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Receptors, Cell Surface/metabolism |
مستخلص: | Diarrhea is a condition in which the individual has about three or more daily bowel movements, followed by changes in stool consistency. It is currently considered as one of the worst public health problems due to the number of cases and deaths involved and difficulty of treatment. Thus, the use of natural products is an alternative for new treatments. Among these possibilities is Farnesol (C Competing Interests: Declaration of competing interest None. (Copyright © 2020. Published by Elsevier B.V.) |
فهرسة مساهمة: | Keywords: Castor oil; Cholera; Farnesol; Gastrointestinal transit; Sesquiterpene |
المشرفين على المادة: | 0 (Antidiarrheals) 0 (Chlorides) 0 (Narcotic Antagonists) 0 (Receptors, Cell Surface) 0 (ganglioside receptor) 36B82AMQ7N (Naloxone) 4602-84-0 (Farnesol) 8001-79-4 (Castor Oil) 9012-63-9 (Cholera Toxin) K7Q1JQR04M (Dinoprostone) |
تواريخ الأحداث: | Date Created: 20200208 Date Completed: 20201201 Latest Revision: 20201201 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.ejphar.2020.172986 |
PMID: | 32032601 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-0712 |
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DOI: | 10.1016/j.ejphar.2020.172986 |