دورية أكاديمية
Synthesis and in vitro investigation of novel cytotoxic pyrimidine and pyrazolopyrimidne derivatives showing apoptotic effect.
العنوان: | Synthesis and in vitro investigation of novel cytotoxic pyrimidine and pyrazolopyrimidne derivatives showing apoptotic effect. |
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المؤلفون: | Ragab FA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo 11562, Egypt., Nissan YM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr Elini St., Cairo 11562, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt., Seif EM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt. Electronic address: ph.emad.seif@gmail.com., Maher A; Biochemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt., Arafa RK; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, 12578 Cairo, Egypt. |
المصدر: | Bioorganic chemistry [Bioorg Chem] 2020 Mar; Vol. 96, pp. 103621. Date of Electronic Publication: 2020 Jan 24. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
مواضيع طبية MeSH: | Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Pyrazoles/*chemistry , Pyrazoles/*pharmacology , Pyrimidines/*chemistry , Pyrimidines/*pharmacology, Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Pyrazoles/chemical synthesis ; Pyrimidines/chemical synthesis |
مستخلص: | A series of novel derivatives of hydrazinylpyrimidines, pyrazolylpyrimidines and 3-amino[3,4-d]pyrazolopyrimidines have been synthesized and tested for their in vitro cytotoxic activity against 60 tumor cell lines by NCI. The in vitro cytotoxic IC Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interests. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
فهرسة مساهمة: | Keywords: Apoptosis; Cytotoxicity; Pyrazolopyrimidine hybrids; Pyrimidine based hybrids |
المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Pyrazoles) 0 (Pyrimidines) |
تواريخ الأحداث: | Date Created: 20200210 Date Completed: 20210224 Latest Revision: 20210224 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.bioorg.2020.103621 |
PMID: | 32036162 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2120 |
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DOI: | 10.1016/j.bioorg.2020.103621 |