دورية أكاديمية
أعرض في EDS

Efflux pump inhibition controls growth and enhances antifungal susceptibility of Fusarium solani species complex.

التفاصيل البيبلوغرافية
العنوان: Efflux pump inhibition controls growth and enhances antifungal susceptibility of Fusarium solani species complex.
المؤلفون: A Cordeiro R; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Portela FV; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Pereira LM; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Andrade AR; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Sousa JK; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Aguiar AL; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Pergentino ML; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Sales GS; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Oliveira JS; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Medrano DJ; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Brilhante RS; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Rocha MF; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.; Post Graduate Program in Veterinary Sciences, College of Veterinary Medicine, State University of Ceará, Fortaleza, Ceará, Brazil., Scm Castelo-Branco D; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Sidrim JJ; Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
المصدر: Future microbiology [Future Microbiol] 2020 Jan; Vol. 15, pp. 9-20. Date of Electronic Publication: 2020 Feb 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine
مواضيع طبية MeSH: Antifungal Agents/*pharmacology , Biofilms/*drug effects , Fungal Proteins/*antagonists & inhibitors , Fusarium/*drug effects , Fusarium/*growth & development , Promethazine/*pharmacology, Amphotericin B/pharmacology ; Drug Resistance, Fungal ; Drug Synergism ; Humans ; Membrane Transport Proteins ; Microbial Sensitivity Tests ; Voriconazole/pharmacology
مستخلص: Aim: To evaluate the inhibition of efflux pumps by using promethazine (PMZ) as a strategy to control Fusarium solani species complex (FSSC). Materials & methods: The susceptibility of FSSC strains to PMZ and the interaction between PMZ and antifungals were evaluated. The efflux pump activity was confirmed by flow cytometry with rhodamine 6G. Finally, PMZ was tested against FSSC biofilms. Results: PMZ inhibited FSSC planktonic growth and showed synergism with antifungals. PMZ reduced R6G efflux and inhibited cell adhesion, impaired the development of biofilms and disrupted mature biofilms. PMZ-challenged biofilms showed increased sensitivity to amphotericin B. Conclusion: The study provides indirect evidence of the occurrence of efflux pumps in FSSC and opens a perspective for this target in the control of fusariosis.
فهرسة مساهمة: Keywords: Fusarium solani; antifungal resistance; biofilm resistance; biofilms; fungal keratitis; promethazine; synergism
المشرفين على المادة: 0 (Antifungal Agents)
0 (Fungal Proteins)
0 (Membrane Transport Proteins)
7XU7A7DROE (Amphotericin B)
FF28EJQ494 (Promethazine)
JFU09I87TR (Voriconazole)
SCR Organism: Fusarium solani
تواريخ الأحداث: Date Created: 20200212 Date Completed: 20210405 Latest Revision: 20210405
رمز التحديث: 20231215
DOI: 10.2217/fmb-2019-0186
PMID: 32043371
قاعدة البيانات: MEDLINE
الوصف
تدمد:1746-0921
DOI:10.2217/fmb-2019-0186