دورية أكاديمية
Cross-talk between SUMOylation and ISGylation in response to interferon.
| العنوان: | Cross-talk between SUMOylation and ISGylation in response to interferon. |
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| المؤلفون: | El-Asmi F; INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saints Pères, 75006 Paris, France., McManus FP; Institute for Research in Immunology and Cancer, Québec, Canada., Brantis-de-Carvalho CE; INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saints Pères, 75006 Paris, France., Valle-Casuso JC; Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France., Thibault P; Institute for Research in Immunology and Cancer, Québec, Canada; University of Montréal, Department of Chemistry, Québec, Canada. Electronic address: pierre.thibault@umontreal.ca., Chelbi-Alix MK; INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saints Pères, 75006 Paris, France. Electronic address: mounira.chelbi-alix@parisdescartes.fr. |
| المصدر: | Cytokine [Cytokine] 2020 May; Vol. 129, pp. 155025. Date of Electronic Publication: 2020 Feb 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001- > : Oxford : Elsevier Science Ltd. Original Publication: [Philadelphia, PA] : Saunders Scientific Publications, W.B. Saunders, [c1989- |
| مواضيع طبية MeSH: | Interferon-alpha/*pharmacology , Sumoylation/*drug effects, Antiviral Agents/pharmacology ; Cell Line ; Cell Line, Tumor ; Gene Expression/drug effects ; HEK293 Cells ; HeLa Cells ; Humans ; Signal Transduction/drug effects ; Transcription Factors/metabolism ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitins/metabolism |
| مستخلص: | Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to profile global changes in protein abundance in SUMO3-expressing cells stimulated by IFNα. These analyses revealed the stabilization of several ISG factors including SAMHD1, MxB, GBP1, GBP5, Tetherin/BST2 and members of IFITM, IFIT and IFI families. This process was correlated with enhanced IFNα-induced anti-HIV-1 and HSV-1 activities. Also IFNα upregulated protein ISGylation through increased abundance of E2 conjugating enzyme UBE2L6, and E3 ISG15 ligases TRIM25 and HERC5. Remarkably, TRIM25 depletion blocked SUMO3-dependent protein stabilization in response to IFNα. Our data identify a new mechanism by which SUMO3 regulates ISG product stability and reinforces the relevance of the SUMO pathway in controlling both the expression and functions of the restriction factors and IFN antiviral response. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: HIV-1; HSV-1; IFN; ISG15; Restriction factors; SUMO; Ubiquitin |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Interferon-alpha) 0 (Transcription Factors) 0 (Ubiquitins) EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes) EC 2.3.2.27 (Ubiquitin-Protein Ligases) |
| تواريخ الأحداث: | Date Created: 20200212 Date Completed: 20211007 Latest Revision: 20211007 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.cyto.2020.155025 |
| PMID: | 32044670 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0023 |
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| DOI: | 10.1016/j.cyto.2020.155025 |