دورية أكاديمية
أعرض في EDS

An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains.

التفاصيل البيبلوغرافية
العنوان: An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains.
المؤلفون: Salazar SB; Department of Bioengineering, Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal., Simões RS; Department of Bioengineering, Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal., Pedro NA; Department of Bioengineering, Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal., Pinheiro MJ; Department of Bioengineering, Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal., Carvalho MFNN; Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal., Mira NP; Department of Bioengineering, Institute of Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.
المصدر: Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2020 Feb 10; Vol. 6 (1). Date of Electronic Publication: 2020 Feb 10.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101671827 Publication Model: Electronic Cited Medium: Internet ISSN: 2309-608X (Electronic) Linking ISSN: 2309608X NLM ISO Abbreviation: J Fungi (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2015]-
مستخلص: Fungal infections and, in particular, those caused by species of the Candida genus, are growing at an alarming rate and have high associated rates of mortality and morbidity. These infections, generally referred as candidiasis, range from common superficial rushes caused by an overgrowth of the yeasts in mucosal surfaces to life-threatening disseminated mycoses. The success of currently used antifungal drugs to treat candidiasis is being endangered by the continuous emergence of resistant strains, specially among non-albicans Candida species. In this review article, the mechanisms of action of currently used antifungals, with emphasis on the mechanisms of resistance reported in clinical isolates, are reviewed. Novel approaches being taken to successfully inhibit growth of pathogenic Candida species, in particular those based on the exploration of natural or synthetic chemicals or on the activity of live probiotics, are also reviewed. It is expected that these novel approaches, either used alone or in combination with traditional antifungals, may contribute to foster the identification of novel anti- Candida therapies.
Competing Interests: The authors declare no conflict of interest.
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معلومات مُعتمدة: UID/BIO/04565/2013; UIDB/04565/2020; UID/QUI/00100/2013 and PTDC/BIA-MIC/31515/2017 Fundação para a Ciência e a Tecnologia; 007317 Programa Operacional Regional de Lisboa 2020
فهرسة مساهمة: Keywords: Candida; antifungal drugs; antimicrobials; candidiasis; non-conventional therapeutics; phytotherapeutics and probiotics; resistance to antifungals
تواريخ الأحداث: Date Created: 20200214 Latest Revision: 20240728
رمز التحديث: 20240728
مُعرف محوري في PubMed: PMC7151124
DOI: 10.3390/jof6010023
PMID: 32050673
قاعدة البيانات: MEDLINE
الوصف
تدمد:2309-608X
DOI:10.3390/jof6010023