دورية أكاديمية
أعرض في EDS

Correlation between vaspin and PANSS scores in schizophrenia patients with obesity.

التفاصيل البيبلوغرافية
العنوان: Correlation between vaspin and PANSS scores in schizophrenia patients with obesity.
المؤلفون: Ertekin H; Department of Psychiatry, Canakkale Onsekiz Mart University, Canakkale, Turkey., Uysal S; Department of Biochemistry, Canakkale Onsekiz Mart University, Canakkale, Turkey., Aydın M; Department of Psychiatry, Selcuk University, Konya, Turkey., İlhan B; Department of Psychiatry, Health Sciences University, Konya, Turkey., Ertekin YH; Department of Family Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
المصدر: International journal of psychiatry in medicine [Int J Psychiatry Med] 2020 Jul; Vol. 55 (4), pp. 264-280. Date of Electronic Publication: 2020 Feb 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 0365646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1541-3527 (Electronic) Linking ISSN: 00912174 NLM ISO Abbreviation: Int J Psychiatry Med Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Los Angeles : Sage Publications
Original Publication: 1973- : Farmingdale, N. Y., Baywood Pub. Co.
مواضيع طبية MeSH: Psychiatric Status Rating Scales*, Metabolic Syndrome/*blood , Obesity/*blood , Schizophrenia/*blood , Serpins/*blood, Adult ; Body Mass Index ; Case-Control Studies ; Cholesterol, LDL/blood ; Comorbidity ; Correlation of Data ; Female ; Humans ; Insulin Resistance/physiology ; Male ; Metabolic Syndrome/psychology ; Middle Aged ; Obesity/psychology ; Reference Values ; Schizophrenic Psychology ; Triglycerides/blood ; Waist Circumference
مستخلص: Objective: Metabolic abnormalities such as diabetes, dyslipidemia, abdominal obesity, metabolic syndrome, and abnormal levels of plasma adipokines have been observed in patients with schizophrenia. This study aimed to investigate the differences and correlations of plasma vaspin levels with metabolic parameters in patients with schizophrenia and to compare with healthy controls.
Method: We measured plasma levels of vaspin and metabolic parameters of 100 patients with schizophrenia and 95 healthy controls. Patients with schizophrenia were evaluated with the Positive and Negative Syndrome Scale (PANSS) and The Global Assessment of Functioning.
Results: Mean levels of body mass index, waist circumference, triglyceride, and low-density lipoprotein cholesterol of the patients were statistically higher than those of the healthy controls (p = 0.002, p < 0.001, p = 0.03, and p = 0.002, respectively). Plasma levels of vaspin were 0.96 ± 0.73 ng/ml in patients with schizophrenia and 0.29 ± 0.15 ng/ml in the healthy controls (p < 0.001). Plasma vaspin levels were statistically higher in patients with schizophrenia than healthy controls both in groups with and without metabolic syndrome and obesity (p < 0.001). Plasma vaspin levels showed a positive correlation with triglyceride in patients with schizophrenia (r = 0.26, p = 0.007). There were positive correlations between vaspin and PANSS scores in schizophrenia patients with obesity (PANSS Positive: r = 0.42, p = 0.01; PANSS Negative: r = 0.42, p = 0.01; PANSS General: r = 0.43, p = 0.01; PANSS Total: r = 0.47, p = 0.006).
Conclusions: Our study showed a significant relationship and positive correlation between vaspin and PANSS scores in schizophrenia patients with obesity. Vaspin may play an important role in the metabolic processes of patients with schizophrenia.
فهرسة مساهمة: Keywords: adipokines; insulin resistance; metabolic syndrome; obesity; schizophrenia; vaspin
المشرفين على المادة: 0 (Cholesterol, LDL)
0 (SERPINA12 protein, human)
0 (Serpins)
0 (Triglycerides)
تواريخ الأحداث: Date Created: 20200214 Date Completed: 20210226 Latest Revision: 20210226
رمز التحديث: 20221213
DOI: 10.1177/0091217420905463
PMID: 32050814
قاعدة البيانات: MEDLINE
الوصف
تدمد:1541-3527
DOI:10.1177/0091217420905463