دورية أكاديمية
أعرض في EDS

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.

التفاصيل البيبلوغرافية
العنوان: Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.
المؤلفون: Xu J; Department of Medicine.; Department of Surgery, and., Ma HY; Department of Medicine., Liu X; Department of Medicine.; Department of Surgery, and., Rosenthal S; Department of Medicine., Baglieri J; Department of Medicine.; Department of Surgery, and., McCubbin R; Department of Medicine., Sun M; Department of Medicine., Koyama Y; Department of Medicine.; Department of Surgery, and., Geoffroy CG; Department of Neurosciences, School of Medicine, UCSD, San Diego, California, USA.; Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, Bryan, Texas, USA., Saijo K; Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, California, USA., Shang L; Department of Surgery, and., Nishio T; Department of Surgery, and., Maricic I; Department of Medicine., Kreifeldt M; Department of Neuroscience, Scripps Research Institute, La Jolla, California, USA., Kusumanchi P; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.; Roudebush VA Medical Center, Indianapolis, Indiana, USA., Roberts A; Department of Neuroscience, Scripps Research Institute, La Jolla, California, USA., Zheng B; Department of Neurosciences, School of Medicine, UCSD, San Diego, California, USA., Kumar V; Department of Medicine., Zengler K; Department of Pediatrics., Pizzo DP; Department of Pathology, and., Hosseini M; Department of Pathology, and., Contet C; Department of Neuroscience, Scripps Research Institute, La Jolla, California, USA., Glass CK; Department of Cellular and Molecular Medicine, School of Medicine, UCSD, San Diego, California, USA., Liangpunsakul S; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.; Roudebush VA Medical Center, Indianapolis, Indiana, USA.; Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana, USA., Tsukamoto H; Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; VA Greater Los Angeles Healthcare System, Los Angeles, California, USA., Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA., Karin M; Department of Pharmacology, School of Medicine, UCSD, San Diego, California, USA., Brenner DA; Department of Medicine., Koob GF; Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland, USA., Kisseleva T; Department of Surgery, and.
المصدر: JCI insight [JCI Insight] 2020 Feb 13; Vol. 5 (3). Date of Electronic Publication: 2020 Feb 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]-
مواضيع طبية MeSH: Alcohol Drinking*, Interleukin-17/*blood , Liver Diseases, Alcoholic/*prevention & control , Signal Transduction/*drug effects, Animals ; Astrocytes/immunology ; Ethanol/administration & dosage ; Humans ; Interleukin-17/immunology ; Liver Diseases, Alcoholic/metabolism ; Liver Diseases, Alcoholic/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/immunology ; Nuclear Receptor Subfamily 1, Group F, Member 3/antagonists & inhibitors
مستخلص: Chronic alcohol abuse has a detrimental effect on the brain and liver. There is no effective treatment for these patients, and the mechanism underlying alcohol addiction and consequent alcohol-induced damage of the liver/brain axis remains unresolved. We compared experimental models of alcoholic liver disease (ALD) and alcohol dependence in mice and demonstrated that genetic ablation of IL-17 receptor A (IL-17ra-/-) or pharmacological blockade of IL-17 signaling effectively suppressed the increased voluntary alcohol drinking in alcohol-dependent mice and blocked alcohol-induced hepatocellular and neurological damage. The level of circulating IL-17A positively correlated with the alcohol use in excessive drinkers and was further increased in patients with ALD as compared with healthy individuals. Our data suggest that IL-17A is a common mediator of excessive alcohol consumption and alcohol-induced liver/brain injury, and targeting IL-17A may provide a novel strategy for treatment of alcohol-induced pathology.
References: Microbiome. 2017 Oct 17;5(1):141. (PMID: 29041989)
Science. 2016 Feb 26;351(6276):933-9. (PMID: 26822608)
J Immunol. 2002 Jul 15;169(2):642-6. (PMID: 12097364)
Cell Cycle. 2011 Jun 1;10(11):1764-71. (PMID: 21555919)
RMD Open. 2017 Feb 15;3(1):e000284. (PMID: 28243466)
Nat Immunol. 2008 Jun;9(6):641-9. (PMID: 18454151)
Nat Protoc. 2013 Mar;8(3):627-37. (PMID: 23449255)
J Immunol. 2009 Jul 15;183(2):865-73. (PMID: 19542376)
Trends Neurosci. 2007 Aug;30(8):399-406. (PMID: 17629579)
Gastroenterology. 2011 Nov;141(5):1572-85. (PMID: 21920463)
Curr Pathobiol Rep. 2016 Mar;4(1):27-35. (PMID: 27239399)
Alcohol Clin Exp Res. 2016 Aug;40(8):1791-2. (PMID: 27364225)
Gastroenterology. 2012 Sep;143(3):765-776.e3. (PMID: 22687286)
J Immunol. 2011 Apr 1;186(7):4481-9. (PMID: 21346238)
Alcohol Clin Exp Res. 2013 Mar;37(3):425-34. (PMID: 23347220)
Hepatology. 2015 Jan;61(1):129-40. (PMID: 25132354)
Alcohol Alcohol. 1990;25(2-3):217-30. (PMID: 2198037)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
J Clin Invest. 2009 Jan;119(1):61-9. (PMID: 19075395)
Neuropsychopharmacology. 2010 Jan;35(1):217-38. (PMID: 19710631)
Acta Neuropathol. 2015 May;129(5):625-37. (PMID: 25716179)
Alcohol Clin Exp Res. 2017 Aug;41(8):1432-1443. (PMID: 28618018)
Nat Rev Immunol. 2009 Aug;9(8):556-67. (PMID: 19575028)
Neuropsychopharmacology. 2008 Mar;33(4):867-76. (PMID: 17551540)
J Neuroimmunol. 2015 Aug 15;285:169-79. (PMID: 26198936)
Nature. 2006 May 11;441(7090):231-4. (PMID: 16648837)
Genome Biol. 2010;11(3):R25. (PMID: 20196867)
Hepatology. 2013 Jul;58(1):314-24. (PMID: 23424168)
Int J High Risk Behav Addict. 2016 Feb 13;5(2):e26907. (PMID: 27622168)
Int Rev Neurobiol. 2014;116:251-73. (PMID: 25172478)
Immunity. 2015 Dec 15;43(6):1023-4. (PMID: 26682973)
J Exp Med. 2010 Mar 15;207(3):535-52. (PMID: 20176803)
Alcohol Clin Exp Res. 2007 Oct;31(10):1759-71. (PMID: 17850646)
J Clin Invest. 2005 Feb;115(2):209-18. (PMID: 15690074)
Alcohol Clin Exp Res. 2004 Dec;28(12):1829-38. (PMID: 15608599)
Bioinformatics. 2010 Jan 1;26(1):139-40. (PMID: 19910308)
Brain Behav Immun. 2011 Jun;25 Suppl 1:S146-54. (PMID: 21377524)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Genome Biol. 2014 Feb 03;15(2):R29. (PMID: 24485249)
Neuron. 2014 Jan 22;81(2):229-48. (PMID: 24462092)
Immunity. 2004 Oct;21(4):467-76. (PMID: 15485625)
Pharmacogenomics J. 2018 Jul;18(4):578-589. (PMID: 29305589)
Behav Brain Res. 2017 Apr 14;323:172-176. (PMID: 28161446)
Hepatology. 2016 Oct;64(4):1343-55. (PMID: 26940353)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Neuropharmacology. 2015 Feb;89:352-9. (PMID: 25446779)
Hepatology. 2009 Feb;49(2):646-57. (PMID: 19177575)
J Hepatol. 2015 Feb;62(2):388-97. (PMID: 25457206)
Sci Rep. 2017 Mar 10;7:41779. (PMID: 28281545)
Nature. 2015 Feb 26;518(7540):547-51. (PMID: 25470051)
J Immunol. 2010 Aug 15;185(4):2502-15. (PMID: 20624949)
J Neurosci. 2006 May 3;26(18):4930-9. (PMID: 16672668)
Neuropharmacology. 2017 Aug 1;122:56-73. (PMID: 28159648)
Nat Med. 2017 Jul;23(7):829-838. (PMID: 28604704)
J Exp Med. 2001 Aug 20;194(4):519-27. (PMID: 11514607)
Front Integr Neurosci. 2013 Dec 30;7:105. (PMID: 24416005)
Alcohol Clin Exp Res. 2016 Sep;40(9):1802-16. (PMID: 27476876)
Genes Brain Behav. 2011 Apr;10(3):264-75. (PMID: 21091635)
Cell. 2009 Oct 30;139(3):485-98. (PMID: 19836068)
معلومات مُعتمدة: R21 AA024935 United States AA NIAAA NIH HHS; R01 NS093055 United States NS NINDS NIH HHS; P42 ES010337 United States ES NIEHS NIH HHS; R01 NS054734 United States NS NINDS NIH HHS; R01 AA025208 United States AA NIAAA NIH HHS; R01 CA100660 United States CA NCI NIH HHS; R01 AA026685 United States AA NIAAA NIH HHS; R37 AI043477 United States AI NIAID NIH HHS; R21 AA024198 United States AA NIAAA NIH HHS; R01 DK099205 United States DK NIDDK NIH HHS; U01 AA022614 United States AA NIAAA NIH HHS; U01 AA027681 United States AA NIAAA NIH HHS; P50 AA011999 United States AA NIAAA NIH HHS; P60 AA006420 United States AA NIAAA NIH HHS; I01 CX000361 United States CX CSRD VA; R01 AI043477 United States AI NIAID NIH HHS; R01 AA021491 United States AA NIAAA NIH HHS; R01 AA020864 United States AA NIAAA NIH HHS; R01 DK101737 United States DK NIDDK NIH HHS; I01 RX002483 United States RX RRD VA; R01 CA234128 United States CA NCI NIH HHS; R01 DK107682 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Addiction; Fibrosis; Gastroenterology; Mouse models
المشرفين على المادة: 0 (IL17A protein, human)
0 (Il17a protein, mouse)
0 (Interleukin-17)
0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20200214 Date Completed: 20210621 Latest Revision: 20210914
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7098802
DOI: 10.1172/jci.insight.131277
PMID: 32051339
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-3708
DOI:10.1172/jci.insight.131277