دورية أكاديمية
Alterations in cerebellar grey matter structure and covariance networks in young people with Tourette syndrome.
| العنوان: | Alterations in cerebellar grey matter structure and covariance networks in young people with Tourette syndrome. |
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| المؤلفون: | Sigurdsson HP; School of Psychology, University of Nottingham, UK. Electronic address: hilmar.sigurdsson@newcastle.ac.uk., Jackson SR; School of Psychology, University of Nottingham, UK; Institute of Mental Health, School of Medicine, University of Nottingham, UK., Jolley L; School of Psychology, University of Nottingham, UK., Mitchell E; School of Psychology, University of Nottingham, UK., Jackson GM; Institute of Mental Health, School of Medicine, University of Nottingham, UK. |
| المصدر: | Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2020 May; Vol. 126, pp. 1-15. Date of Electronic Publication: 2020 Jan 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Masson Country of Publication: Italy NLM ID: 0100725 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1973-8102 (Electronic) Linking ISSN: 00109452 NLM ISO Abbreviation: Cortex Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Milan : Masson Original Publication: Varese. |
| مواضيع طبية MeSH: | Tics*/diagnostic imaging , Tourette Syndrome*/diagnostic imaging, Adolescent ; Animals ; Cerebral Cortex ; Child ; Gray Matter/diagnostic imaging ; Humans ; Magnetic Resonance Imaging |
| مستخلص: | Tourette syndrome (TS) is a childhood-onset neurological disorder characterised by the occurrence of motor and vocal tics and the presence of premonitory sensory/urge phenomena. Functional neuroimaging studies in humans, and experimental investigations in animals, have shown that the genesis of tics in TS involve a complex interaction between cortical-striatal-thalamic-cortical brain circuits and additionally appears to involve the cerebellum. Furthermore, structural brain imaging studies have demonstrated alterations in grey matter (GM) volume in TS across a wide range of brain areas, including alterations in GM volume within the cerebellum. Until now, no study to our knowledge has yet investigated how GM structural covariance networks linked to the cerebellum may be altered in individuals with TS. In this study we employed voxel-based morphometry, and a 'seed-to-voxel' structural covariance network (SCN) mapping approach, to investigate alterations in GM cerebellar volume in people with TS, and alterations in cerebellar SCNs associated with TS. Data from 64 young participants was entered in the final analysis, of which 28 had TS while 36 were age-and sex-matched healthy volunteers. Using the spatially unbiased atlas template of the cerebellum and brainstem (SUIT) atlas, we found reduced GM volume in cerebellar lobule involved in higher-order cognitive functions and sensorimotor processing, in patients. In addition, we found that several areas located in frontal and cingulate cortices and sensorimotor network in addition to subcortical areas show altered structural covariance with our cerebellar seed compared to age-matched controls. These results add to the increasing evidence that cortico-basal ganglia-cerebellar interactions play an important role in tic symptomology. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| معلومات مُعتمدة: | G0901321 United Kingdom MRC_ Medical Research Council; MR/M009122/1 United Kingdom MRC_ Medical Research Council; G0901321 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Cerebellum; Structural covariance networks; Tourette syndrome; VBM; sMRI |
| تواريخ الأحداث: | Date Created: 20200217 Date Completed: 20210621 Latest Revision: 20210926 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.cortex.2019.12.022 |
| PMID: | 32062139 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1973-8102 |
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| DOI: | 10.1016/j.cortex.2019.12.022 |